Carcinoma Ex Pleomorphic Adenoma: Rare Malignant Salivary Gland Neoplasm
SandhyaTamgadge, AvinashTamgadge, Treville Pereira* and Simona Naik
Department of Oral & Maxillofacial Pathology and Microbiology Dr D Y Patil Dental College & Hospital, Maharashtra, India
- *Corresponding Author:
- Treville Pereira
Department of Oral & Maxillofacial Pathology
and Microbiology Dr D Y Patil Dental College & Hospital
Sector 7, Nerul, Navi Mumbai, Maharashtra, India
E-mail: trevillepereira@gmail. com
Received Date: March 10, 2014; Accepted Date: April 24, 2014; Published Date: May 02, 2014
Citation: Tamgadge S, Tamgadge A, Pereira T, Naik S (2014) Carcinoma Ex Pleomorphic Adenoma: Rare Malignant Salivary Gland Neoplasm. Oral Hyg Health 2: 133. (2014) Carcinoma Ex Pleomorphic Adenoma: Rare Malignant Salivary Gland Neoplasm. J Oral Hyg Health 2:132. doi: 10.4172/2332-0702.1000132
Copyright: © 2014 Sandhya T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Carcinoma ex-pleomorphic adenoma (CXPA) is a rare, aggressive, poorly understood malignancy of the salivary gland. The clinical findings typical of this tumor include history of a slow growing, ulcerated, painless mass that enlarges rapidly. Histologically, CXPA is characterized by the presence of carcinomatous transformation in pleomorphic adenoma which includes abnormal nuclear changes with mitoses, dystrophic calcification, vascular or neural invasion or both by lesional cells along with local and distant metastasis. Immunohistochemical staining in the carcinoma areas revealed positive reaction for epithelial membrane antigen and p63 protein but negative for vimentin. We report a case of a CXPA in the hard palate and discuss its clinical and histopathological findings.