alexa Coeliac Disease-Related Antibodies Appearance in a IgA
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
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Case Report

Coeliac Disease-Related Antibodies Appearance in a IgA Deficiency Celiac Girl after Starting the Gluten-Free Diet

Raffaella Nenna1*, Laura Petrarca1, Gerarda Mastrogiorgio1, Matteo Florio1, Chiara Imondi2, Maria Bavastrelli1, Margherita Bonamico1 and Fabio Massimo Magliocca2

1Department of Paediatrics, University of Rome, Italy

2Experimental Medicine and Pathology, “Sapienza” University of Rome, Italy

*Corresponding Author:
Dr. Raffaella Nenna
Department of Paediatrics “Sapienza” University of Rome
Viale Regina Elena 324, 00161 Rome, Italy
Tel: 39 06 49979358
Fax: 39 06 49979358

Received date: November 29, 2015, Accepted date: December 14, 2015, Published date: December 20, 2015

Citation: Nenna R, Petrarca L, Mastrogiorgio G, Florio M, Imondi C, et al. (2015) Coeliac Disease-Related Antibodies Appearance in a IgA Deficiency Celiac Girl after Starting the Gluten-Free Diet. J Gastrointest Dig Syst 5:362. doi:10.4172/2161-069X.1000362

Copyright:© 2015 Nenna R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Celiac disease (CD) is a gluten-dependent autoimmune enteropathy which occurs in genetically predisposed individuals. CD can manifest in a typical form (with gastrointestinal symptoms), with an atypical form (iron-deficiency anemia, headache, recurrent aphthous stomatitis) or be asymptomatic (silent form). Over the last decades CD prevalence increased (1.2%), mainly due to the improvement and diffusion of screening tools such as anti-gliadin, anti-endomysium and anti-tissue transglutaminase antibodies. The authors report a case of a 39 months old IgA deficiency girl with a severe abdominal distention and iron deficiency anemia, negative for CD-related antibodies, who was diagnosed celiac. Surprisingly, after six months of gluten-free diet, the patient showed the appearance of IgG class – CD specific antibodies.


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