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Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x
| Paula Norinho Oliveira1, Rita Caldas1, Cátia Rodrigues1, Mak F Kok1, Cátia Rasteiro1, Soledade Ferreira1, Luísa Sousa1, Carla Barbedo2, Teresa Paula Teles1 and Humberto S Machado3* | |
| 1Department of Gynecology and Obstetrics of Centro Hospitalar Entre Douro e Vouga , EPE, Santa Maria da Feira, Portugal | |
| 2Centro de Patologia do Desenvolvimento, Porto, Portugal | |
| 3Department of Anesthesiology, Centro Hospitalar do Porto, Porto, Portugal | |
| Corresponding Author : | Humberto S Machado Department of Anesthesiology Centro Hospitalar do Porto, Porto, Portugal Tel: +351 22 207 7500 E-mail: hjs.machado@gmail.com |
| Received: September 29, 2015 Accepted: November 12, 2015 Published: November 19, 2015 | |
| Citation: Oliveira PN, Caldas R, Rodrigues C, Kok MF, Rasteiro C, et al. (2015) Congenital Acute Lymphoblastic Leukemia with Placental Involvement: Case Report x. J Preg Child Health 2:204. doi:10.4172/2376-127X.1000204 | |
| Copyright: © 2015 Oliveira PN. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
| Related article at Pubmed, Scholar Google | |
Abstract
The authors describe a case of congenital acute lymphoblastic leukaemia (ALL), with extensive placental involvement, causing intrauterine fetal growth restriction and unexpected fetal demise at 33 weeks. Although unusual, other congenital tumours, including neuroblastoma and hepatoblastoma, can metastasize to the placenta. Congenital malignancy must be considered in the differential diagnosis of an abnormally large placenta. This case emphasizes the important role of careful histopathologic examination of the placenta which, combined with immunohistochemistry and clinicopathologic correlation, may establish the accurate diagnosis.
