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Correlation Between Serum and Salivary House Dust Mite Specific Immunoglobulins in Allergic Rhinitis (AR) Patients and Non-Allergic Rhinitis Matched Controls| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(4): 257
  • DOI: 10.4172/2161-119X.1000257

Correlation Between Serum and Salivary House Dust Mite Specific Immunoglobulins in Allergic Rhinitis (AR) Patients and Non-Allergic Rhinitis Matched Controls

Sethu T Subha1*, Loy Heng She2, Wong Shew Fung3, Davendralingam Sinniah4 and Valuyeetham Kamaru Ambu5
1Department of Surgery/ENT, Faculty of Medicine & Health Sciences, University Putra Malaysia, , Malaysia
2Canberra Hospital, Yamba drive, Garran, , Australia
3Department of Pathology, International Medical University, Malaysia
4Department of Paediatrics, Clinical School Seremban, International Medical University, Malaysia
5Department of ENT, Hospital Tuanku Jaafar Seremban, Ministry of Health Malaysia, Seremban, , Malaysia
*Corresponding Author : Sethu T Subha, Department of Surgery/ENT, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400, Serdang, Malaysia, Tel: 0060123459420, Fax: 0060389475217, Email: [email protected]

Received Date: Apr 27, 2016 / Accepted Date: Aug 09, 2016 / Published Date: Aug 16, 2016

Abstract

Background and objectives: Allergic rhinitis (AR) is characterised by inflammation of the nasal mucosa associated with IgE mediated immune response to specific allergens. Studies have shown that the most commonly implicated aeroallergens in AR are house dust mites. Dermatophagoides pteronyssinus (Dp), Dermatophagoides farinae (Df) and Blomia tropicalis (Bt) are the three most common mite species in Malaysia. Previous studies have reported the presence of high IgE and non-IgE antibodies in both serum and saliva samples of AR patients, but the correlation between them is not clear. The objective of this study was to determine the levels and correlation of mite specific IgE and IgA against D. farinae and B. tropicalis in serum and salivary samples of AR patients and nonallergic rhinitis matched controls.

Methods: A total of 205 adults were studied, they included 103 with AR and 102 healthy controls matched for age and gender. Among the 103 AR patients, 20 had concomitant asthma. Indirect ELISA was used to measure the levels of serum and salivary IgE and IgA respectively.

Results: Correlation between the serum and salivary antibody levels was analysed using Spearman correlation test, while the differences between groups were analysed using Mann-Whitney test and Kruskal Wallis test. Serum IgE and IgA levels against D. farinae and B. tropicalis were higher in AR patients. Salivary IgA against D. farinae and salivary IgE against B. tropicalis were significantly higher in AR patients. Serum and salivary IgE levels were positively correlated with serum and salivary IgA levels in AR subjects against both mite species. There was no significant difference in antibodies levels between asthmatic AR and non-asthmatic AR to both mite species in serum and saliva samples. Antibodies levels were not correlated with severity of signs and symptoms in AR patients.

Conclusion: The presence of high IgA level in saliva might be a potential investigation tool to test for allergic rhinitis when blood sampling is not an option.

Keywords: Allergic rhinitis; Dermatophagoides pteronyssinus ; Dermatophagoides farina ; Blomia tropicalis ; Serum immunoglobulins; Salivary immunoglobulins

Citation: Subha ST, She LH, Fung WS, Sinniah D, Ambu VK (2016) Correlation Between Serum and Salivary House Dust Mite Specific Immunoglobulins in Allergic Rhinitis (AR) Patients and Non-Allergic Rhinitis Matched Controls. Otolaryngol (Sunnyvale) 6:257. Doi: 10.4172/2161-119X.1000257

Copyright: © 2016 Subha ST, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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