alexa Correlation of LDL Cholesterol with Maternal and Cord B
ISSN: 2376-127X

Journal of Pregnancy and Child Health
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Research Article

Correlation of LDL Cholesterol with Maternal and Cord Blood Heme Oxygenase 1 in Preeclampsia

Kharb S*, Tiwari R and Nanda S
Department of Biochemistry, Sharma University of Health Sciences, Rohtak, Haryana, India
Corresponding Author : Kharb S
Department of Biochemistry
Sharma University of Health Sciences
Rohtak, Haryana, India
Tel: 919812016036
E-mail: [email protected]
Received: January 29, 2016 Accepted: February 19, 2016 Published: February 26, 2016
Citation: Kharb S, Tiwari R, Nanda S (2016) Correlation of LDL Cholesterol with Maternal and Cord Blood Heme Oxygenase 1 in Preeclampsia. J Preg Child Health 3:225. doi:10.4172/2376-127X.1000225
Copyright: © 2016 Kharb S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective Emerging evidence supports an important role for the heme oxygenase system (HO-1) in the maintenance of a healthy pregnancy, especially during pathological challenge. HO-1 is widely accepted to be a highly sensitive and reliable marker of oxidative stress. Hence the present study was planned to analyse heme oxygenase-1 and lipid profile in maternal and cord blood venous samples of normal pregnant and preeclamptic women. Methods Fifty pregnant women were selected and grouped as group 1 (control) comprising of twenty five normotensive women immediately after delivery; group 2 (study group) comprising of age-and sex-matched twenty five preeclamptic women. Study samples were drawn (maternal venous blood and umbilical cord blood) and heme oxygenase-1 was analyzed by competitive enzyme linked immunosorbent assay and lipid profile was analyzed enzymatically. Results Cord blood hemeoxygenase-1 levels in preeclamptic women were significantly higher than those of normotensive women (p<0.001). There was significant rise in serum heme oxygenase 1 levels in preeclamptic women as compared to normotensive pregnant women (p<0.001). LDL levels were positively correlated with HO 1 in preeclamptic women (r=0.236, p>0.05) and negatively correlated in normotensive women (r=-0.111, p>0.05), indicating the induction of HO 1 by LDL. Conclusion The findings of high serum heme oxygenase-1 levels in maternal and cord blood in preeclampsia supports the role of oxidative stress and excessive inflammatory response in the pathogenesis of preeclampsia.


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