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C-Reactive Protein and Endothelin-1 are Weakly Associated with Cardiovascular Diseases in Stable Chronic Obstructive Pulmonary Disease Patients. The Results of a Cross-Sectional Study| Abstract
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Journal of Cardiac and Pulmonary Rehabilitation
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  • Research Article   
  • J Card Pulm Rehabil 2017, Vol 1(2): 118

C-Reactive Protein and Endothelin-1 are Weakly Associated with Cardiovascular Diseases in Stable Chronic Obstructive Pulmonary Disease Patients. The Results of a Cross-Sectional Study

Emanuela Tudorache, Voicu Tudorache*, Cristian Oancea, Bogdan Timar, Ovidiu Fira Mladinescu, Diana Manolescu, Rodica Dan, Stela Iurciuc and Lucian Petrescu
1Department of Pulmonology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
2Department of Biostatistics and Medical Informatics, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
3Department of Radiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
4Department of Cardiology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
5Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
*Corresponding Author : Voicu Tudorache Professor, Department of Pulmonology, Victor Babes University of Medicine and Pharmacy, 2 Eftimie Murgu, 30041 Timisoara, Romania, Tel: +40722619148, Email: [email protected]

Received Date: Nov 20, 2017 / Accepted Date: Dec 04, 2017 / Published Date: Dec 09, 2017

Abstract

Background and objectives: Exacerbations, systemic manifestations and comorbidities have a great impact on the morbidity and mortality of COPD. Our study aimed to evaluate the presence and the strength of a possible association between inflammatory biomarkers (especially CRP), the presence of CVD and muscular impairment in patients with stable COPD.
Materials and methods: We included 59 patients with stable COPD who were divided in two study cohorts: group A-27 COPD patients with normal levels of C-reactive protein (CRP) and group B-32 patients with increased levels of CRP at two measurements within 6 month. In group B were also analyzed Endothelin-1 (ET-1), Tumor Necrosis Factor Alpha (TNF-α) and Interleukin 6 (IL6). Both groups performed spirometry, 6 min walk distance test (6MWD), Maximal Expiratory Pressure (MEP) and Maximal Inspiratory Pressure (MIP), CAT (COPD Assessment Test), dynamometry, body composition, ECG, carotid ultrasound and echocardiography.
Results:
Patients with persistent systemic inflammation when compared with normal CRP ones, had a higher age (64 yrs vs. 58 yrs, p=0.048), higher prevalence of CVD (3 vs. 1, p=0.005), dyslipidemia (61% vs. 39%, p=0.117), more pronounced upper extremity muscle weakness (dynamometry 4.5 vs. 5.5, p=0.048) and respiratory muscle weakness (MEP 50.3 vs. 57.3, p=0,038). They also had a slightly more limited exercise tolerance (6MWD 394.1 m vs. 430.6 m p=0.273), were slightly more symptomatic (CAT 21 pts vs. 16.5 points, p=0.141) and had a higher body mass index (26.5 kg/m2 vs. 24.5 kg/m2, p=0.187). Elderly patients had increased levels of CRP, TNF-α and IL-6.
Conclusion: In a context of stable COPD, persistently elevated CRP levels are associated with higher age, higher prevalence of CVD and more severe muscle weakness. Biomarkers like ET-1, TNF-α and IL6 do not reveal additional contributions in these systemic inflamed COPD group.

Keywords: Endothelin-1; CRP, Endothelium; Atherosclerosis; Muscular dysfunction; Stable COPD

Citation: Tudorache E, Tudorache V, Oancea C, Timar B, Mladinescu OF, et al. (2017) C-Reactive Protein and Endothelin-1 are Weakly Associated with Cardiovascular Diseases in Stable Chronic Obstructive Pulmonary Disease Patients. The Results of a Cross-Sectional Study. J Card Pulm Rehabil 1: 118.

Copyright: © 2017 Tudorache E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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