alexa CT scanning protocol in washin/washout method to reduce
ISSN:2167-7964

OMICS Journal of Radiology
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Research Article

CT scanning protocol in washin/washout method to reduce the effect of xenoninduced flow activation on xenon-enhanced computed tomography calculations: cerebral blood flow and partition coefficient

Shigeru Sase1,2*, Hideharu Nakano3 and Mitsuru Honda4
1Anzai Medical Co Ltd., Japan
2Department of Neurosurgery, Toho University Omori Medical Center, Japan
3Department of Radiology, Toho University Omori Medical Center, Japan
4Department of Critical Care Center, Toho University Omori Medical Center, Japan
Corresponding Author : Shigeru Sase
Anzai Medical Co Ltd.
3-6-25 Nishi-Shinagawa
Shinagawa-ku, Tokyo 141-0033,Japan
Tel: +81-3-3779-1611
Fax: +81-3-3779-6606
E-mail: [email protected]
Received January 06, 2015; Accepted March 30, 2015; Published April 03, 2015
Citation: Sase S, Nakano H, Honda M (2015) CT scanning protocol in washin/washout method to reduce the effect of xenon-induced flow activation on xenon-enhanced computed tomography calculations: cerebral blood flow and partition coefficient. OMICS J Radiol 4:182. doi: 10.4172/2167-7964.1000182
Copyright: © 2015 Sase S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: It has been required to reduce the effect of xenon-induced flow activation (Xe activation) in xenonenhanced computed tomography (Xe-CT). The goal of this work was to propose a CT scanning protocol in the washin/washout method that could reduce the Xe-activation effect on calculated cerebral blood flow (CBF) and partition coefficient (lambda) in Xe-CT.

Methods: In the 4-min washin/4-min washout protocol with 1-min interval scans, the effect of Xe activation was calculated by theoretical simulations under the following scanning protocols based on the reported transcranial Doppler measurements: A: 1-min intervals, B: skip scans during the first 2 min in washout, and C: no scan in washout. For ten healthy subjects, CBF and lambda for the cortical regions of the right and left middle cerebral artery (MCA) territories were evaluated in protocols A and B.

Results: Due to Xe activation, simulated CBF for gray matter was changed by 13%, 7% and 6%; simulated lambda for gray matter was changed by 2%, 4% and 4%; simulated CBF for white matter was changed by 11%, 10% and -1%; and simulated lambda for white matter was changed by 14%, 14% and 133% in protocols A, B and C, respectively. For the ten subjects, the mean differences between protocols A and B in obtained CBF were 1.85 (P=0.0337) and 2.23 mL/100g/min (P=0.0077), and those in obtained lambda were -0.042 (P<0.0001) and -0.041 (P<0.0001) for the right and left MCA territories respectively. This demonstrated that gray matter CBF by protocol A was statistically larger than that by protocol B, and gray matter lambda by protocol A was statistically smaller than that by protocol B, which agreed with the theoretical simulation results.

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