Cutaneous Neurofibroma of the Ear Pinna: A Report of Two Cases
*Corresponding Author: Rajat Bhende, Department of Neurology, Bharati Vidyapeeth Dental College, PuneWarning: Undefined variable $university_str in /efsdata/omicsonline.org/httpdocs/includes/articles_utility.php on line 338
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, India, Email: docrcb@rediffmail.com
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Copyright: © 2021 Rajat B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Aim and Objective: To present the current considerations, natural history and treatment modalities of cutaneous neurofibromas (cNF).
Methods: Cutaneous Neurofibroma experts from various research and clinical backgrounds reviewed the terms currently in use for cNF as well as the clinical, histologic, and radiographic features of these tumors using available data.
Results: Neurofibromas develop within nerves, soft tissue, and skin. The primary distinction between cNF and other neurofibromas is that cNF are limited to the skin whereas other neurofibromas may involve the skin, but are not limited to the skin. There are important cellular, molecular, histologic, and clinical features of cNF. Each of these factors is discussed in consideration of a clinicopathologic framework for cNF.
Conclusion: The development of various treatment options for neurofibroma requires formulation of diagnostic criteria that encompass the clinical and histologic features of these tumors. However, the rear several areas of overlap between cNF and other neurofibromas that make distinctions between cutaneous and other neurofibromas more difficult, requiring careful deliberation with input across the multiple disciplines that encounter these tumors and ultimately, prospective validation. The ultimate goal of this work is to facilitate accurate diagnosis and meaningful therapeutics for CNF.