alexa Declinol, a Complex Containing Kudzu, Bitter Herbs (Gentian, Tangerine Peel)and Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test (AUDIT) Scores in Moderate to Heavy Drinkers: A Pilot Study | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Declinol, a Complex Containing Kudzu, Bitter Herbs (Gentian, Tangerine Peel)and Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test (AUDIT) Scores in Moderate to Heavy Drinkers: A Pilot Study

Steven Kushner1, David Han2, Marlene Oscar-Berman3, William Downs B4, Margaret A Madigan4, John Giordano5, Thomas Beley5, Scott Jones5, Debmayla Barh6, Thomas Simpatico7, Kristina Dushaj8, Raquel Lohmann8, Eric R Braverman8,9, Stephen Schoenthaler10, David Ellison11 and Kenneth Blum4-9,12,13*

1Department of Nutritional Science, ALM Research & Development, Inc., Tampa, FL, USA

2Department of Management Science and Statistics, University of Texas at San Antonio, San Antonio, Texas, USA

3Department of Psychiatry, Anatomy & Neurobiology, Boston MA and Boston University School of Medicine, Boston, Massachusetts, USA

4Department of Molecular Nutrition, Synaptamine Inc., Austin, Texas, USA

5Department of Holistic Medicine, G & G Health Care Services, LLC, North Miami Beach, Florida, USA

6Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India

7Department of Psychiatry, Global Integrated Services Unit of Vermont Center for Clinical & Translational Science, University of Vermont College of Medicine, Burlington, VT, USA

8Department of Clinical Neurology, PATH Foundation NY, New York, New York, USA

9Department of Psychiatry, University of Florida, College of Medicine & McKnight Brain Institute, Gainesville, Florida, USA

10Department of Sociology, California State University, Turlock, CA, USA

11 Department of Research & Development, Premier Naturals, Inc., Cincinnati, OH, USA

12 Dominion Diagnostics, LLC, North Kingstown, Rhode Island, USA

13Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, CA, USA

*Corresponding Author:
Kenneth Blum, PhD
Department of Psychiatry and McKnight Brain Institute
University of Florida, College of Medicine
PO Box 103424 Gainesville, Florida, USA
Tel: 619-890-2167
Fax: 352-392- 9887
E-mail: [email protected]

Received date: May 13, 2013; Accepted date: June 12, 2013; Published date: July 02, 2013

Citation: Kushner S, Han D, Oscar-Berman M, William Downs B, Madigan MA, et al. (2013) Declinol, a Complex Containing Kudzu, Bitter Herbs (Gentian, Tangerine Peel) and Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test (AUDIT) Scores in Moderate to Heavy Drinkers: A Pilot Study. J Addict Res Ther 4:153. doi:10.4172/2155-6105.1000153

Copyright: © 2013 Kushner S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

It is well established that inherited human aldehyde dehydrogenase 2 (ALDH-2) deficiency reduces the risk for alcoholism. Kudzu plants and extracts have been used for 1,000 years in traditional Chinese medicine to treat alcoholism. Kudzu contains daidzin, which inhibits ALDH-2 and suppresses heavy drinking in rodents. Decreased drinking due to ALDH-2 inhibition is attributed to aversive properties of acetaldehyde accumulated during alcohol consumption. However not all of the anti-alcohol properties of diadzin are due to inhibition of ALDH-2. This is in agreement with our earlier work showing significant interaction effects of both pyrozole (ALDH-2 inhibitor) and methyl-pyrozole (non-inhibitor) and ethanol’s depressant effects. Moreover, it has been suggested that selective ALDH 2 inhibitors reduce craving for alcohol by increasing dopamine in the nucleus accumbens (NAc). In addition there is significant evidence related to the role of the genetics of bitter receptors (TAS2R) and its stimulation as an aversive mechanism against alcohol intake. The inclusion of bitters such as Gentian & Tangerine Peel in Declinol provides stimulation of gut TAS2R receptors which is potentially synergistic with the effects of Kudzu. Finally the addition of Radix Bupleuri in the Declinol formula may have some protective benefits not only in terms of ethanol induced liver toxicity but neurochemical actions involving endorphins, dopamine and epinephrine. With this information as a rationale, we report herein that this combination significantly reduced Alcohol Use Disorders Identification Test (AUDIT) scores administered to ten heavy drinkers (M=8, F=2; 43.2 ± 14.6 years) attending a recovery program. Specifically, from the pre-post comparison of the AUD scores, it was found that the score of every participant decreased after the intervention which ranged from 1 to 31. The decrease in the scores was found to be statistically significant with the p-value of 0.00298 (two-sided paired test; p-value = 0.00149 for one-sided test). Albeit this being a small pilot, we are encouraged about these significant results, and caution any interpretation until larger controlled studies are executed.

Keywords

Recommended Conferences
Share This Page
Top