alexa Effects of Ampicillin/Sulbactam Dose and Dosing Frequen
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Effects of Ampicillin/Sulbactam Dose and Dosing Frequency in Elderly Patients with Nursing- and Healthcare-Associated Pneumonia (Nhcap)

Yoshitaka Yamazaki1*, Mariko Sugawara1, Norihiko Goto1, Takashi Shinbo1, Kazuhisa Shimodaira2, Keisuke Nakamura3 and Noriko Fujiwara4
1Department of Respiratory and Infectious Diseases, Nagano Prefectural Suzaka Hospital, Japan
2Department of Internal Medicine, Nagano Prefectural Suzaka Hospital, Japan
3Division of Pharmacy, Nagano Prefectural Suzaka Hospital, Japan
4Division of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Japan
*Corresponding Author : Yoshitaka Yamazaki
Department of Pulmonary and Infectious Diseases
Nagana Prefectural Suzaka Hospital, 1332 Suzaka
Suzaka City, Nagano prefecture, 382-0091, Japan
Tel: +81-26-245-1650
Fax: +81-26-245-3240
E-mail: [email protected]
Received: January 21, 2016 Accepted: February 06, 2016 Published: February 12, 2016
Citation: Yamazaki Y, Sugawara M, Goto N, Shinbo T, Shimodaira K, et al. (2016) Effects of Ampicillin/Sulbactam Dose and Dosing Frequency in Elderly Patients with Nursing- and Healthcare-Associated Pneumonia (Nhcap). J Infect Dis Ther 4:267. doi: 10.4172/2332-0877.1000267
Copyright: © 2016 Yamazaki Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Japan has the most rapidly aging population in the world. This study aimed to examine the differences in the efficacy of ampicillin/sulbactam (ABPC/SBT) alone under different daily doses and daily dosing frequencies in elderly patients receiving healthcare at home and in elderly nursing home residents with pneumonia onset requiring hospitalization for treatment. By applying the Clinical Practice Guidelines for Nursing- and Healthcare-associated Pneumonia (NHCAP) of the Japanese Respiratory Society (JRS), we retrospectively analyzed clinical data, dose, dosing period, and the efficacy of antimicrobial agents, as well as outcomes of patients with NHCAP or community acquired pneumonia (CAP) who had been hospitalized at our department during the 3-year period of 2009 through 2011. The mean age of NHCAP patients (n=587) was 85 ± 9 years, significantly higher than the 77 ± 16 years of CAP patients (n=319). The serum albumin level in NHCAP patients was significantly lower than that in CAP patients. Among NHCAP patients, 82.5% received ABPC/SBT alone as the first-line therapy, with 50.7% receiving 1.5 g three times daily and 22.8% receiving 3 g twice daily. The mortality rate during hospitalization in the 1.5-g three-times-daily group was 12.4%, resulting in a significantly decrease as compared with the 3-g twice-daily group of 20.9% (p<0.01). In our study, which targeted the elderly in Japan, it was revealed that ABPC/SBT is an appropriate first choice of antibiotics in treating NHCAP and that administering 1.5 g three times daily is a suitable way of administration.


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