Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital | OMICS International | Abstract
ISSN: 2161-1165

Epidemiology: Open Access
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Research Article

Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital

Shalini Duggal*, Nandini Duggal, Charoo Hans and Ashish Kumar Duggal

PGIMER and Dr Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, Delhi-110001, India

Corresponding Author:
Shalini Duggal
Specialist, Department of Microbiology
Dr Baba Saheb Ambedkar Hospital
Sector-6, Rohini, Delhi-110085, India
Tel: 009810921982
Fax: 91-11-27055585
E-mail: [email protected]

Received Date: June 25, 2014; Accepted Date: July 25, 2014; Published Date: August 1, 2014

Citation: Duggal S, Duggal N, Hans C, Duggal AK (2014) Epidemiology of Cryptococcal Meningitis Associated with HIV in an Indian Hospital .Epidemiology (Sunnyvale) 4:166. doi:10.4172/2161-1165.1000166

Copyright: © 2014 Duggal S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..


Cryptococcus neoformans is an emerging pathogen especially in the setting of HIV infected patients with meningitis. The infection usually manifests in patients with impaired cell mediated immunity. Forty six culture positive cases of cryptococcal meningitis were identified over a period of three years from a tertiary care institute in Delhi. The patients were predominantly males (91%) of reproductive age group, mostly residing in and around Delhi. Most significant co-infections were HIV infection in 93% and tuberculosis in 43.5% cases. All forty six strains belonged to Cryptococcus neoformans var grubii, molecular type VN I, mating type α (MAT α). There was 100% susceptibility to amphotericin B and azoles, one isolate was resistant to 5-fluorocytosine (MIC 64 μg/ml). Cerebrospinal fluid in symptomatic HIV patients should be carefully screened for Cryptococcus spp. which should be identified and also typed for epidemiological purposes.