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Evaluation of Stearylamine-Modified Liposomes for the Oral Vaccine Adjuvant | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
Open Access

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Research Article

Evaluation of Stearylamine-Modified Liposomes for the Oral Vaccine Adjuvant

Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Japan
Corresponding Author : Watarai S
Division of Veterinary Science
Graduate School of Life and Environmental Sciences
Osaka Prefecture University, 1-58 Rinkuohraikita
Izumisano, Osaka 598-8531, Japan
Tel: +81-72-463-5720
Fax: +81-72-463-5720
E-mail: [email protected]
Received March 25, 2014; Accepted April 27, 2014; Published May 02, 2014
Citation: Watarai S and Sasaki Y (2014) Evaluation of Stearylamine-Modified Liposomes for the Oral Vaccine Adjuvant. J Infect Dis Ther 2:141. doi:10.4172/2332-0877.1000141
Copyright: © 2014 Watarai S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The usefulness of stearylamine (SA)-modified liposomes for the oral vaccine adjuvant in the induction of immune responses was evaluated. Mice were orally immunized withunmodified liposomes containing ovalbumin (OVA) (group I), OVA-containing monophosphoryl lipid A (MPL)-modified liposomes (group II), OVA-having SA-modified liposomes (group III) or OVA alone (group IV). After immunization, significant OVA-specific antibodies were detected in the serum and intestine from mice of groups I to III, but not in group IV. Especially, intestinal IgG and IgA antibody responses against OVA were significantly higher in mice of group III than in groups I and II. When sera were analyzed for isotype distribution,OVA-specific IgG1 antibody responses were noted in mice of groups I and II, whereas the induction of OVA-specific IgG1 and IgG3 antibody responses was observed in mice of group III. Moreover, substantial production of IFN-γ(Th1-type) and IL-4 (Th2 type) was demonstrated in spleen cells from mice of group III in vitro. These results suggest that the SA-modified liposomes would serve effectively as mucosal vaccine adjuvant for inducing humoral and cell-mediated immune responses.

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