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Case Report

First Report of Three Major Oncogenic Viruses: Human Papillomavirus, Epstein-Barr Virus And Merkel Cell Polyomavirus in Penile Cancer

Baez CF1, da Rocha WM2, Afonso LA2, Carestiato FN2, Guimarães MAAM1, Cavalcanti SMB2 and Varella RB2*
1Department of Preventive Medicine, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio do Janeiro, Brazil
2Department of Microbiology and Parasitology, Universidade Federal Fluminense, Brazil
Corresponding Author : Rafael B Varella
Laboratory of Virology
Department of Microbiology and Parasitology
Universidade Federal Fluminense, Brazil
Tel: 55 21 2560-8344
E-mail: rvarella@id.uff.br
Received: July 16, 2015 Accepted: September 03, 2015 Published: September 09, 2015
Citation: Baez CF, da Rocha WM, Afonso LA, Carestiato FN, Guimarães MAAM et al. (2015) First Report of Three Major Oncogenic Viruses: Human Papillomavirus, Epstein-Barr Virus And Merkel Cell Polyomavirus in Penile Cancer. J Infect Dis Ther 4:233. doi:10.4172/2332-0877.1000233
Copyright: © 2015 Baez CF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

We report here in first hand a case of triple infection caused by oncogenic viruses: HPV16, EBV-2 and MCPyV, in a squamous cell carcinoma of penis with an unfavorable outcome. Although reports on multiple viral infections in tumors are increasing, we do not know whether they are simply co-detected in the tissue or playing a synergistic role in the tumorigenesis. Studies addressing a putative co-stimulatory effect among these agents are needed in order to improve our comprehension of cell transformation.

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