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Hindi Review Article
Fundamentals and Applications of Impedimetric and Redox Capacitive Biosensors
Adriano Santos1, Jason J Davis2* and Paulo R Bueno1*
1Department of Physical Chemistry, Chemistry Institute, São Paulo State University (Unesp), São Paulo, Brazil
2Department of Chemistry, University of Oxford, Oxford, United Kingdom
- *Corresponding Author:
- Paulo R Bueno
Nanobionics research group, Department of Physical Chemistry
Chemistry Institute, São Paulo State University (Unesp)
55 Prof. Francisco Degni Street, ZIP Code 14800-060, Araraquara
São Paulo, Brazil
Tel: +55 16 3301 9642
Fax: +55 16 3322 2308
E-mail:prbueno@iq.unesp.br
Jason J Davis
Department of Chemistry, University of Oxford
South Parks Road, Oxford, OX1 3QX, UK
E-mail: jason.davis@chem.ox.ac.uk
Received Date: May 12, 2014; Accepted Date: May 29, 2014; Published Date: June 02, 2014
Citation:Santos A, Davis JJ, Bueno PR (2014) Fundamentals and Applications of Impedimetric and Redox Capacitive Biosensors. J Anal Bioanal Tech S7:016.doi: 10.4172/2155-9872.S7-016
Copyright: © 2014 Santos A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Electroanalyses have brought a huge amount to our understanding of interfaces generally. When applied to surfaces which have been specifically engineered so as to recruit targets from an analytical solution, potent sensors can be derived. These may be based on a multitude of different analytical methods all typified by specific requirements and surface configurations. This short review examines the application of amperometric and impedimetric methods to the detection of biomarkers of clinical relevance. Basic principles are introduced with examples at both planar and “nanofunctionalised” interfaces comprising immobilized antibodies/antigens and oligonucleotide receptors. A particular focus is made of new developments in impedance and impedance derived capacitance spectroscopy.
