Histology of Pancreas of Wistar Rats Treated with Aqueous Extract of Afang Leaf
Received Date: Jul 31, 2018 / Accepted Date: Aug 31, 2018 / Published Date: Sep 10, 2018
Methods: Wistar rats, eighteen adult Wistar rats weighing between 80 g-150 g allotted into three groups of six rats each was used for this study. Animals in group 1 served as the control group were fed with normal rat chew and distilled water, while group 2 and 3 served as the experimental groups treated with Gnetum africanum leaf extract, orally for 21 days. Group 2 (low dose group) animals were treated with 0.3 ml/kg body weight of the extract, while group 3 (high dose group) animals were treated with 0.5 ml/kg body weight of the extract. At the end of experiment, all animals were sacrificed under chloroform inhalation and the pancreas removed for histological observation using Haematoxylin and Eosin (H & E) stain.
Results: Histological observations from the study showed normal histological findings in the control and low dose group with no observable pathology. Meanwhile the high dose treated group showed pathological observation suggesting a prognosis of acinar cell cystadenocarcinoma.
Conclusion: From the result of the study, it may be deduced that consumption of Gnetum africanum, at moderate dosage, may have no adverse effect on the pancreas, but at high dosages, the extract may cause some pathological distortion to the microanatomy of the pancreas.
Keywords: Gnetum africanum; Wistar rat; Pancreas; Microanatomy
Citation: Obeten KE, Christian E (2018) Histology of Pancreas of Wistar Rats Treated with Aqueous Extract of Afang Leaf . J Phytochemistry Biochem 2: 111.
Copyright: © 2018 Obeten KE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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