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Hindi Review Article
Human Interleukin 2 (IL-2) Promotion of Immune Regulation and ClinicalOutcomes: A Review
Marcela Petrolini Capobianco1*, Gustavo Capatti Cassiano2, Adriana Antônia da Cruz Furini3, Luciane Moreno Storti de Melo4, Cláudia Regina Bonini Domingos1 and Ricardo Luiz Dantas Machado51Graduate Program in Genetics, São Paulo State University, São José do Rio Preto, São Paulo, Brazil
2University of Campinas, Campinas, São Paulo, Brazil
3Graduate Program in Health Sciences, School of Medicine of São José do Rio Preto, São José do Rio Preto, São Paulo, Brazil
4Department of Biology, Federal University of Sergipe, Aracajú, Sergipe, Brazil
5Laboratory of Malaria Immunogenetics, Evandro Chagas Institute/Health Ministry, Pará, Brazil
- *Corresponding Author:
- Marcela Petrolini Capobianco
Centro de Investigação de Microrganismos Depto
de Doenças Dermatológicas
Infecciosas e Parasitárias
FAMERP - Faculdade de Medicina de São José do Rio Preto Av. Brigadeiro Faria Lima
5416 CEP: 15090-000, Vila São Pedro
Brazil
Tel: +551732015736
Fax: +551732015736
E-mail: mpcapobianco@yahoo.com.br
Received date: June 27, 2016; Accepted date: July 21, 2016; Published date: July 21, 2016
Citation: Capobianco MP, Cassiano, GC, da Cruz Furini AA, Storti de Melo LM, Domingos CRB, et al. (2016) Human Interleukin 2 (IL-2) Promotion of Immune Regulation and Clinical Outcomes: A Review. J Cytokine Biol 1:109. doi: 10.4172/jcb.1000109
Copyright: © 2016 Capobianco MP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract
Interleukin 2 (IL-2) is a monomeric glycoprotein that is primarily produced by activated CD4+ T cells, CD8+ T cells and dendritic cells. It is characterized as a proinflammatory cytokine that is secreted by Th1 cells. IL-2 plays a central role in the activation of regulatory T cells to produce the cytokines tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). IL-2 may also enhance the cytolytic activity of natural killer cells, thereby ensuring their significance in the control of the immune response, and effectively participate in the pathogenesis of several pathological conditions, such as cancer and metabolic, infectious, autoimmune and inflammatory diseases. We emphasize the importance of studies of IL-2 and discuss perspectives resulting from our increasing understanding of genetic diversity and its role in the immune response.
