alexa

GET THE APP

Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Hypocretin/Orexin Receptor Antagonism and the Promise of Anticravingmedications: Myth or Panacea? | OMICS International | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Hypocretin/Orexin Receptor Antagonism and the Promise of Anticravingmedications: Myth or Panacea?

Benjamin Boutrel*

Center for Psychiatric Neuroscience, Lausanne University Hospital, CH-1008 Prilly, Switzerland

*Corresponding Author:
Benjamin Boutrel, PhD
Center for Psychiatric Neuroscience
Lausanne University Hospital
CH-1008 Prilly Switzerland
Tel: 0041 21 643 69 47
Fax: 0041 21 643 69 50
E-mail: [email protected]

Received November 02, 2011; Accepted December 14, 2011; Published December 20, 2011

Citation: Boutrel B (2011) Hypocretin/Orexin Receptor Antagonism and the Promise of Anticraving medications: Myth or Panacea? J Addict Res Ther S4:005. doi:10.4172/2155-6105.S4-005

Copyright: © 2011 Boutrel B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A general consensus acknowledges that drug consumption (including alcohol, tobacco and illicit drugs) constitutes the leading cause of preventable death worldwide. An even more pessimistic observation suggests that drug abuse is not only a major cause of mortality but also it significantly deteriorates the quality of life of individuals suffering from the long-term debilitating effect of the disease. Despite the large body of evidence delineating the cellular and molecular adaptations induced by chronic drug consumption, the brain mechanisms responsible for drug craving and relapse remain insufficiently understood, and even the most recent developments in the field have not brought significant improvement in the management of drug dependence. Here, we review recent evidence demonstrating an important role for the hypocretin (orexin) neuropeptide system in regulating drug reward, and notably in preventing drug relapse. We then propose to discuss why disrupting the hypocretin system may serve as an anticraving medication since during the transition to addiction, the hypocretin system, normally orchestrating the appropriate levels of alertness required for the execution of goal-oriented behaviors, may be compromised and contribute to the pathological state by eliciting compulsive drug craving. Finally, we question the undesirable effects associated with a pharmacologically impaired hypocretin system, which may limit the applicability of the anticipated anticraving action of such a medication.

Recommended Conferences

11th World congress on Addictive Disorders & Addiction Therapy

London, United Kingdom
Google Scholar citation report
Citations : 4229

Journal of Addiction Research & Therapy received 4229 citations as per Google Scholar report

Journal of Addiction Research & Therapy peer review process verified at publons
Indexed In
  • CAS Source Index (CASSI)
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • Academic Keys
  • JournalTOCs
  • SafetyLit
  • China National Knowledge Infrastructure (CNKI)
  • Electronic Journals Library
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • SWB online catalog
  • Virtual Library of Biology (vifabio)
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
Share This Page
https://betlike.fun/ https://betlikegiris.xyz/ https://betpark.fun/ https://betticketgiris.xyz/ https://bettilt.club/ https://betvole.fun/ https://casinoeuro.fun/ https://celtabet.fun/ https://cratosslot.fun/
Top