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Image-Guided Whole Abdominal Radiation Therapy in Gynecologic Cancers
| Aaron H Wolfson* | |
| University of Miami Miller School of Medicine, USA | |
| Corresponding Author : | Aaron H. Wolfson University of Miami Miller School of Medicine 1475 NW 12th Avenue D-31 Miami, FL 33136, USA Tel: 305-243-4210 Fax: 305-243-4363 E-mail: awolfson@med.miami.edu |
| Received May 04, 2013; Accepted July 15, 2013; Published July 22, 2013 | |
| Citation: Wolfson AH (2013) Image-Guided Whole Abdominal Radiation Therapy in Gynecologic Cancers. OMICS J Radiology 2:134. doi: 10.4172/2167-7964.1000134 | |
| Copyright: © 2013 Wolfson AH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
The use of adjuvant Whole Abdominal Radiation Therapy (WART) in gynecologic cancers has not achieved widespread use for a variety of reasons. Several phase III trials comparing WART with adjuvant chemotherapy (CT) in both uterine and ovarian cancers have demonstrated marginal improvement in survival favoring CT over WART. However, the dose of conventionally delivered WART has been historically limited due in large part to the low threshold of normal organ tolerance in the upper abdomen associated with significant late effects of the bowel and kidneys in particular. Yet, with the advent of Image-Guided Radiation Therapy (IGRT), the possibility of dose reduction to nearby organs at risk along with the potential to increase target volume dose is now obtainable. This paper will review the current data related to IGRT WART for several different patient populations of gynecologic cancers.
