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Hindi Inhibition of Protease Activity of Periodontopathogens by Purified Lactoferrin and Lactoferrin Supplement
*Corresponding Author: Dr. Yoneda M, Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, 2-15-1, Tamura, Sawara-ku, Fukuoka 814-0193, Japan, Tel: +81-92-801-0411, Fax: +81-92-801-4909, Email: yoneda@college.fdcnet.ac.jpReceived Date: Jan 16, 2019 / Accepted Date: Feb 14, 2019 / Published Date: Feb 24, 2019
Citation: Ishii A, Yoneda M, Matsuo T, Omagari S, Suzuki N, et al. (2019) Inhibition of Protease Activity of Periodontopathogens by Purified Lactoferrin and Lactoferrin Supplement. J Oral Hyg Health 7: 250.
Copyright: © 2019 Ishii A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Periodontitis is caused by periodontopathic bacteria such as Porphyromonas gingivalis and Tannerella forsythia. P. gingivalis has several biologic activities such as protease secretion. Inhibition of protease activities of periodontopathogens is one of the most effective strategies to prevent the progression of periodontitis. Lactoferrin, an iron-binding glycoprotein, is considered to be a useful tool for this purpose, and lactoferrin supplements may be effective for health promotion.
In this study, the effect of purified lactoferrin on P. gingivalis and T. forsythia protease was examined. The effect of lactoferrin supplement on protease activity was also tested. The purified lactoferrin inhibited the protease activity of both periodontopathogens. Lactoferrin supplement also exhibited the inhibitory effect.
From these results, lactoferrin and lactoferrin supplement are considered to contribute to the prevention of periodontitis by inhibiting the protease activity of periodontopathogens.
