alexa Isolation of <em>Mycobacterium Bovis</em> from Human Sputum in Zambia: Public Health and Diagnostic Significance | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Isolation of Mycobacterium Bovis from Human Sputum in Zambia: Public Health and Diagnostic Significance

Sydney Malama1,2* Dep., Oslo, Norway John Bwalya Muma3 Francisco Olea-Popelka4 Grace Mbulo5
1Institute of Economic and Social Sciences, University of Zambia, P.O. Box 30900, Lusaka, Zambia
2Department of Food Safety and Infection Biology, Section of Epidemiology and Biostatistics, Norwegian School of Veterinary Science, P.O. Box 8146
3Department of Disease Control, School of Veterinary Medicine, University of Zambia, P.O. Box 32379, Lusaka, Zambia
4College of Veterinary Medicine and Biomedical Sciences, Department of Clinical Sciences, Colorado State University,FortCollins,USA
Corresponding Author : Sydney Malama
Institute of Economic and Social Sciences
University of Zambia, P O Box 30900, Lusaka, Zambia
E-mail: [email protected]
 
Received August 29, 2013; Accepted September 24, 2013; Published October 01, 2013
 
Citation: Malama S, Muma JB, Olea- Popelka F, Mbulo G (2013) Isolation of Mycobacterium Bovis from Human Sputum in Zambia: Public Health and Diagnostic Significance. J Infect Dis Ther 1:114. doi:10.4172/2332-0877.1000114
Copyright: © 2013 Malama S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The WHO reported in 1998 that 3.1% of tuberculosis cases in humans worldwide are attributable to M. bovis and that in 0.4-10% of sputum isolates from patients in African countries, M. bovis is isolated. Sputum samples were collected from a total of 917 smear-positive TB patients enrolled in a national drug resistance survey in the nine provinces of Zambia and another 100 patients enrolled in a separate TB survey conducted in the pastoral area of Namwala district of Southern province of Zambia between 2008 and 2011. Based on Spoligotyping, eight of the isolates from both surveys were confirmed as M. bovis belonging to the SB 0120 Spoligotype. The two surveys provided an opportunity to document isolation of M. bovis from sputum samples from patients diagnosed with TB from both urban and pastoral areas of Zambia. This study therefore, highlights the public health significance of M. bovis in Zambia and the importance of screening for M. bovis as part of routine diagnosis procedures. Hence, a targeted treatment for those human patients suffering from zoonotic tuberculosis is recommended to address important differences in pathology and treatment response between different mycobateria.

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