2476-213X

Journal of Clinical Infectious Diseases & Practice
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Killer Cell Immunoglobulin like Receptors (KIR) Gene Variations in Rheumatic Fever and Rheumatic Heart Disease Patients from North India

Sarkar S#1, Rastogi M#1, Kumar R2 and Chakraborti AN*1

1Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

2School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India

#Both the authors contributed equally to this study

*Corresponding Author:
Chakraborti A
Department of Experimental Medicine and Biotechnology
Post Graduate Institute of Medical Education and Research
Chandigarh- 160012
India
Tel: +91 172 2746277
Fax: +91 172 2744401
E-mail: superoxide14@gmail.com

Received date: January 11, 2016; Accepted date: June 22, 2016; Published date: June 30, 2016

Citation: Sarkar S, Rastogi M, Kumar R, Chakraborti A (2016) Killer Cell Immunoglobulin like Receptors (KIR) Gene Variations in Rheumatic Fever and Rheumatic Heart Disease Patients from North India. J Clin Infect Dis Pract 1:105. doi: 10.4172/2476-213X.1000105

Copyright: © 2016 Sarkar S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The autoimmune sequelae of rheumatic fever (RF) and rheumatic heart disease (RHD) are due to untreated or partially treated pharyngitis caused by Group A streptococcus (GAS). RF/RHD usually affects the genetically susceptible individuals. KIR (Killer cell immunoglobulin like receptor) of NK (natural killer) cell has been documented in susceptibility to various autoimmune diseases. KIR is of activating, inhibitory, pseudo and framework types. In here, 29 patients (pharyngitis, RF and RHD) and controls were studied to establish the association of different KIR genes in development of RF/RHD. KIR genotyping in all the disease groups revealed that the frequency of activating KIR2DS4A and inhibitory KIR2DL5B were less in RHD compared to the control. On the other hand, frequency of activating KIR2DS5A was more in RHD than pharyngitis. A significant difference in the frequency of KIR2DS2A and KIR3DL1B were found in pharyngitis compared to control. Interestingly, the overall data revealed a marked decrease of activating genes in pharyngitis and an increase in RHD. However, in the study, the framework genes were comparatively conserved and pseudo genes did not show any significant change. Thus, the study suggests an association of KIR in the pathogenesis of RF/RHD by demonstrating the variations in specific genotypes. This can be correlated to the prolonged activation of NK cells which may be accountable for regulation of adaptive immune response and self-tolerance. Further study in large cohort may unveil more information regarding the role of KIR in the development of the disease.

Keywords

Top