alexa Lessons Learnt in a 17 Year Old with Fever of Unknown Origin: Haemophagocytic Lymphohistiocytosis-The Most Fatal Outcome of EBV Infection | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Case Report

Lessons Learnt in a 17 Year Old with Fever of Unknown Origin: Haemophagocytic Lymphohistiocytosis-The Most Fatal Outcome of EBV Infection

Ibraheim H*, Yip K and Arami S
Department of Medicine, Princess Royal University Hospital, London, UK
Corresponding Author : Ibraheim H
Department of Medicine, Princess Royal
University Hospital, London, UK
Tel: +44 1689863000
E-mail: [email protected]
Received: September 8, 2015 Accepted: November 6, 2015 Published: November 12, 2015
Citation: Ibraheim H, Yip K, Arami S (2015) Lessons Learnt in a 17 Year Old with Fever of Unknown Origin: Haemophagocytic Lymphohistiocytosis-The Most Fatal Outcome of EBV Infection. J Infect Dis Ther 3:250. doi:10.4172/2332-0877.1000250
Copyright: © 2015 Ibraheim, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

We report a young patient who had persistent fever as a result of the most fatal outcome of an Epstein-Barr Virus infection-haemophagocytic lymphohistiocytosis (EBV-HLH). A 17 year old girl with a background of IgG subclass deficiency presented with a history of fever, sore throat and vomiting. The impression was of EBV related infectious mononucleosis which was supported by a positive monospottest and high EBV DNA levels. Despite a decreasing level of EBV DNA levels, she remained febrile and tachycardic with worsening liver function, cytopenia and no improvement on broad spectrum antimicrobials. Repeated septic screens were negative.
By day 16 HLH was considered and a bone marrow aspirate showed haemphagocytosis. She was started on steroids with a rapid clinical and biochemical response. This case highlights the importance of having a low threshold of suspicion for EBV-HLH in patients with EBV that continue to deteriorate, particularly with a history of immunodeficiency.

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