alexa Long-Chain Polyunsaturated Fatty Acids in Breast-Milk and Erythrocytes and Neurodevelopmental Outcomes in Danish Late-Preterm Infants
ISSN: 2376-127X

Journal of Pregnancy and Child Health
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Research Article

Long-Chain Polyunsaturated Fatty Acids in Breast-Milk and Erythrocytes and Neurodevelopmental Outcomes in Danish Late-Preterm Infants

Stine Brøndum Andersen1*, Lars I Hellgren2, Mette Krogh Larsen3, Henrik Verder1 and Lotte Lauritzen4
1Department of Paediatrics, Holbaek University Hospital, Smedelundsgade, Holbaek, Denmark
2Centre for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Søltofts Plads bygning, Lyngby, Denmark
3Department of Food Science, AU Foulum, Aarhus University, Blichers Allé 20, Tjele, Denmark
4Department of Nutrition, Exercise and Sports, University of Copenhagen, Rolighedsvej, Frederiksberg C, Denmark
Corresponding Author : Stine Brøndum Andersen
Department of Paediatrics
Holbaek University Hospital
Smedelundsgade 60, DK-4300 Holbaek
Tel: +45 20254583
E-mail: [email protected]
Received: February 13, 2015; Accepted: May 01, 2015; Published: May 06, 2015
Citation: Andersen SB, Hellgren LI, Larsen MK, Verder H, Lauritzen L (2015) Long-Chain Polyunsaturated Fatty Acids in Breast-Milk and Erythrocytes and Neurodevelopmental Outcomes in Danish Late-Preterm Infants. J Preg Child Health 2:160. doi: 10.4172/2376-127X.1000160
Copyright: © 2015 Andersen SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: The supply of long-chain polyunsaturated fatty acids (LC-PUFA) during pregnancy and early lactation has been shown to affect cognitive development in preterm infants, but the effect on early neurodevelopment of late-preterm infants has not yet been examined.

Aim: To examine the fatty acid composition of late-preterm human milk and identify possible associations between infant LC-PUFA status and perinatal as well as 1-year neurobehavioral outcomes.

Methods: Mother’s milk and erythrocytes (RBC) were sampled from 53 Danish late-preterm infants (33-36 weeks of gestation) 1 week and 1 month after delivery, and 3 months corrected age. Fatty acid composition was determined by gas-liquid chromatography. Neurodevelopmental outcomes were assessed by the Nicu Network Neurobehavioral Scale (NNNS) at 1 week and 1 month and the Bayley Scales (BSID-III) at 1 year corrected age.

Results: We found that breast-milk content of arachidonic acid (AA) and docosahexaenoic acid (DHA) was similar to reported fatty acid compositions of term human milk. Infant RBC-AA decreased from 1 week to 1 month of age and the size of the decrease was associated with better NNNS-scores at 1 month, specifically on regulation (p=0.03). Infant RBC-AA at 1 month was also associated with a lower 1-year corrected age BSID-III score of receptive language (p=0.05) and fine motor development (p=0.03). Infant RBC-DHA did not decrease significantly after delivery and was not associated with any of the developmental outcomes.

Conclusion: Breast-milk LC-PUFA content was reflected in the RBC LC-PUFA status of the infant. Early RBC-AA status was associated with both early and long-term neurobehavioral development, but not in a consistent way.


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