alexa Low-Frequency, Whole Body Vibration Induced Neurite Outgrowth by Pc12m3 Cells with Impaired Nerve Growth Factor-Induced Neurite Outgrowth
ISSN: 2165-7025

Journal of Novel Physiotherapies
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Research Article

Low-Frequency, Whole Body Vibration Induced Neurite Outgrowth by Pc12m3 Cells with Impaired Nerve Growth Factor-Induced Neurite Outgrowth

Yoshihisa Koike1*, Reiko Tutida1, Yuko Hayashi1, Yoko Yamanishi1 and Yoshio Kano2
1Department of Occupational Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima, Mihara City, Hiroshima 723-005, Japan
2Department of Occupational Therapy, School of Health Science, Kibi international University, 8 Iga-machi Takahashi City, Okayama 716-8508, Japan
Corresponding Author : Yoshihisa Koike
Department of Occupational Therapy
Faculty of Health and Welfare
Prefectural University of Hiroshima, Mihara City
Hiroshima 723-005, Japan
Tel: +81-848-60-1212
E-mail: [email protected]
Received October 30, 2014; Accepted February 05, 2015; Published February 12, 2015
Citation: Koike Y, Tutida R, Hayashi Y, Yamanishi Y, Kano Y (2015) Low-Frequency, Whole Body Vibration Induced Neurite Outgrowth by Pc12m3 Cells with Impaired Nerve Growth Factor-Induced Neurite Outgrowth. J Nov Physiother 5:249. doi: 10.4172/2165-7025.1000249
Copyright: © 2015 Koike Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Purpose: To investigate the effects of very low-frequency whole body vibration (WBV) stimulation using PC12 m3 cells.

Methods: Mutant, drug-hypersensitive, PC12 m3 cells were obtained by means of continuous culture of neural PC12 cells and then stimulated by low-frequency vibration at frequencies of 7–13 Hz for 5–20 min with simultaneous exposure to nerve growth factor (NGF).

Results: The frequency of neurite outgrowth by PC12 m3 cells induced by 7-Hz vibratory stimulation was approximately 3-fold greater than that induced by NGF alone. Moreover, activated cyclic-AMP responsive element (CRE)-binding protein (CREB) expression was induced in PC12 m3 cells stimulated by 7-Hz vibration.

Conclusion: Low-frequency vibratory stimulation induces neurite outgrowth via a p38 mitogen-activated protein kinase/CREB signaling pathway in PC12 m3 cells. Together, these results suggest that WBV is an efficient method to stimulate neurite growth.


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