alexa Macroscopic ICRS Poorly Correlates with O Driscoll Histological Cartilage Repair Assessment in a Goat Model
ISSN: 2329-910X

Clinical Research on Foot & Ankle
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Research Article

Macroscopic ICRS Poorly Correlates with O Driscoll Histological Cartilage Repair Assessment in a Goat Model

Kok AC1*, van Bergen CJA1, Tuijthof GJM1,2, Klinkenbijl MN1, van Noorden CJF3, van Dijk CN1 and Kerkhoffs GMMJ1
1Department of Orthopedic Surgery, Orthopedic Research Center Amsterdam, Academic Medical Center Amsterdam, the Netherlands
2BioMechanical Engineering, Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, the Netherlands
3Department of Cell Biology and Histology, Academic Medical Center Amsterdam, University of Amsterdam, the Netherlands
Corresponding Author : Kok AC
Orthopedic Research Center Amsterdam
Academic Medical Center, Amsterdam, The Netherlands
Tel: +31071 5277057
E-mail: [email protected]
Received: June 19, 2015 Accepted: September 23, 2015 Published: September 26, 2015
Citation: Kok AC, van Bergen CJA, Tuijthof GJM, Klinkenbijl MN, van Noorden CJF, et al. (2015) Macroscopic ICRS Poorly Correlates with O’Driscoll Histological Cartilage Repair Assessment in a Goat Model. Clin Res Foot Ankle 3:173. doi:10.4172/2329-910X.1000173
Copyright: © 2015 Kok AC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Background: The purpose of this research was to evaluate whether the macroscopic assessment of repair cartilage quality of talar osteochondral defects in a goat model using the ICRS score is in correspondence with histological assessment using the O’Driscoll histology score.

Methods: 32 caprine samples with six mm osteochondral defects treated with microfracture were analyzed six months postoperatively using high-resolution digital images. Two observers independently scored the defects using the ICRS (0-12 points). Histological analysis was performed by one expert histologist using the O’Driscoll Score (0-24 points) on 5 μm slices stained with Masson Goldner and Safranin O. Total ICRS and O’Driscoll scores as well as sub items were compared using a Spearman correlation coefficient (p<0.05).

Results: The median ICRS for Observer 1 and 2 were 6.5 (range: 4-11) and 6.5 (range: 3-11). The median O’Driscoll score was 11.5 (range: 3-20). The correlation of the total ICRS scores and the O’Driscoll score was not significant, nor was the correlation of sub items (p>0.05).

Conclusion: This animal study suggests that isolated macroscopic ICRS assessment of cartilage repair tissue does not correlate well with histological assessment. Possible explanations may be limitations of surface assessment compared to analysis deeper into the tissue and the necessity of more elaborate macroscopic assessment including hypertrophy, colour, lesion size, location and degenerative status of the joint. Techniques that are more accurate, precise and reliable, such as histology, dGEMERIC and T2 mapping MRI, contrast enhanced CT or optical coherence tomography (OCT), should be considered as alternatives or at least as complimentary methods.


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