Mitochondrial DNA Haplogroups in Patients with Alzheimer Probable in Guadalajara, Mexico
Genaro Gabriel Ortiz1*, Verónica Loera-Castañeda1, Lucila Sandoval-Ramírez2, Miguel Ángel Macías-Islas3, Gracia Viviana González- Enríquez1, Luis J. Flores-Alvarado1,4, Irma E. Velázquez-Brizuela5,
Alfredo Celis de la Rosa4 and Fermín P. Pacheco-Moisés6
1Laboratorio de Desarrollo-Envejecimiento; Enfermedades Neurodegenerativas. División de Neurociencias. Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jalisco México
- Corresponding Author:
- Genaro Gabriel Ortiz
Laboratorio de Desarrollo- Envejecimiento
Centro de Investigación Biomédica de Occidente
Instituto Mexicano del Seguro Social
Sierra Mojada 800 cp 43440 Guadalajara, Jalisco, México
E-mail: [email protected]om
Received date: October 20, 2011; Accepted date: November 09, 2011; Published November 11, 2011
Citation: Ortiz GG (2011) Mitochondrial DNA Haplogroups in Patients with Alzheimer Probable in Guadalajara, MÃ©xico. J Alzheimers Dis 1:103. doi:
Copyright: © 2011 Ortiz GG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and aims . It has been suggested that mitochondrial dysfunction is relevant to Alzheimer disease (AD) and some mitochondrial haplogroups could be related to the risk of AD. Therefore, in this work we have genotyped mtDNA haplogroups in Mexican patients with AD and their respective matched controls. Methods: Haplotyping of 33 AD patients and 49 healthy control subjects was performed using polymerase chain reaction/digest identification of key polymorphic sites in the mitochondrial genome. Results: Mitochondrial haplogroup A is the most frequent in AD patients and controls followed by haplogroup B. The haplogroup C was the least frequent in the control group and it was absent in the AD group. The frequency of haplogroup D was significantly higher in the AD group than in the control group (p = 0.03). Conclusion: There is clear association between the frequency of haplogroup D and Alzheimer disease in the analyzed population from Guadalajara, Mexico. Interestingly the haplogroup C was absent in the AD group. These data requires further study in a larger population to identify these differences more clearly.