alexa

GET THE APP

Mono or Dual-Ligand Nanoparticles: Theoretical Study | OMICS International | Abstract
ISSN: 2469-9764

Industrial Chemistry
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Mono or Dual-Ligand Nanoparticles: Theoretical Study

*Corresponding Author:

Copyright: © 0  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
To read the full article Peer-reviewed Article PDF image

Abstract

Dual-ligand nanocarriers have been developed to target over-expressed receptors, such as epidermal growth factor receptors (EGFR) and folate receptors (FR), in cancer cells. The dual ligand technique has been developed to enhance nanocarrier targeting, by binding to two kinds of over-expressed receptors instead of one. This study theoretically designs the binding of dual-ligand to two types of over-expressed receptors on cancer cells. We developed molecular theory that considers van der Waals, steric, and electrostatic interactions under a decoupled self-consistent field (SCF) approach. Our developed theory determines the dual-ligand-receptor binding regulations, and it can be applied for triple-ligand nanocarriers. The developed theory shows that dual-ligand nanocarriers are more effective than two mono-ligand nanocarriers combined. Manipulating some of the environmental parameters, such as salt concentration, temperature, and pH, along with the design parameters, such as polyelectrolytes pKa, number of polymers, and their density, can improve the functionality of the therapeutic nanocarriers. Besides, the size of the targeted nanocarriers is determined in this work to an efficient binding to two or more receptors on the cancer cell.

Keywords

Top