Mood Symptoms are Related to Psychotic Symptoms in Severe Alzheimer's Disease | OMICS International | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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Research Article

Mood Symptoms are Related to Psychotic Symptoms in Severe Alzheimer's Disease

Koji Hori1*, Kimiko Konishi2, Hiroi Tomioka1, Masayuki Tani3, Genshin Minegishi4, Hiroaki Tanaka4, Sachiko Yokoyama1, Tomonori Oshio1 and Mitsugu Hachisu5

1Department of Psychiatry, Showa University Northern Yokohama Hospital, Kanagawa, Japan

2Tokyo Metropolitan Tobu Medical Center for Persons with Developmental/Multiple Disabilities, Tokyo, Japan

3Department of Psychiatry, Showa University Karasuyama Hospital, Tokyo, Japan

4Department of Psychiatry, Showa University Fujigaoka Hospital, Kanagawa, Japan

5Department of Clinical Psychopharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan

*Corresponding Author:
Koji Hori Department of Psychiatry
Showa University Northern Yokohama Hospital
35-1 Chigasakichuo, Tsuzukiku, Yokohama-City
Kanagawa, 224-8503, Japan
Tel: +81-45-949-7000
Fax: +81-45-949-7927
E-mail: [email protected]

Received October 27, 2011; Accepted January 04, 2012; Published January 08, 2012

Citation: Hori K, Konishi K, Tomioka H, Tani M, Minegishi G, et al. (2012) Mood Symptoms are Related to Psychotic Symptoms in Severe Alzheimer’s Disease. J Addict Res Ther S5:002. doi:10.4172/2155-6105.S5-002

Copyright: © 2012 Hori K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The aim of the present study was to investigate the relationship between cognitive dysfunction and the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease (AD). The subjects were 79 consecutive AD patients referred because of BPSD. First, we investigated the correlation between cognitive function and the severity of dementia or each symptom domain of BPSD. Then the AD patients were divided into a group with higher performance (n=40, HP group) and a group with lower performance (n=39, LP group). Subsequently, we compared BPSD between these two groups and a factor analysis of BPSD was conducted in each group. We found that disturbance of activity and disturbance of diurnal rhythm were negatively correlated with cognitive function (p<0.05), while affective disturbance was positively correlated with cognitive function (p<0.05). Factor analysis showed that a mood cluster (affective disturbance plus anxieties and phobias) was associated with a psychiatric cluster (paranoid and delusional ideation plus hallucinations) and with aggressiveness in the LP group. These results indicate that disease progress of AD infl uences the BPSD of AD patients in two ways. That is, behavioral symptoms become more severe and the mood cluster conversely becomes milder but is connected to the psychiatric cluster and aggressiveness.