Neuropeptides in the Development of Colon Cancer
- Corresponding Author:
- Oliveira EC
Department of Surgery, School of Medicine
Federal University of Goiás, Brazil
E-mail: [email protected]
Received: April 05, 2016 Accepted: April 30, 2016 Published:May 06, 2016
Citation:Garcia SB, Minto SB, Kannen V, Oliveira EC (2016) Neuropeptides in the Development of Colon Cancer. Can Surg 1:104.
Copyright: © 2016 Garcia SB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Neuropeptides modulate a broad range of physiologic processes as paracrine and endocrine factors in peripheral systems. These complex neuronal activities are only possible because neurons can release one or more neuropeptides together, which can signal as neuromodulators. Given that a large number of neuropeptides has been reported, it would be almost impossible to describe such complexity herein. Therefore, we will focus only on those molecules with more known pronounced activity throughout the development of colon cancer. Given that the intestinal neuro-immune axis plays a significant role in regulating the severity of inflammation, it possibly has a pivotal role in the colon cancer development. Nevertheless, the precise role and the real impact of neuropeptides in the development of colon cancer, remains to be fully elucidated.