Physico-Chemical Characterization and Analytical Development for Sodium Azumolene, a Potential Drug Designed to Fight Malignant HyperthermiaJosilene Chaves Ruela Corrêa*, Marcelo Augusto Cavaretti Hiene and Hérida Regina Nunes Salgado
Department of Pharmaceutics, School of Pharmaceutical Sciences, Univ Estadual Paulista, Brazil
- *Corresponding Author:
- Josilene Chaves Ruela Corrêa
Department of Pharmaceutics, School of Pharmaceutical Sciences
Univ Estadual Paulista. Rodovia Araraquara-Jaú
km 1, 14801-902, Araraquara, Brazil
Tel: +55 16 3301 4681
E-mail: [email protected]
Received date: November 20, 2013; Accepted date: December 19, 2013; Published date: December 21, 2013
Citation: Corrêa JCR, Hiene MAC, Salgado HRN (2013) Physico-Chemical Characterization and Analytical Development for Sodium Azumolene, a Potential Drug Designed to Fight Malignant Hyperthermia. J Anal Bioanal Tech 5: 177. doi: 10.4172/2155-9872.1000177
Copyright: © 2013 Corrêa JCR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.