Dersleri yüzünden oldukça stresli bir ruh haline sikiş hikayeleri bürünüp özel matematik dersinden önce rahatlayabilmek için amatör pornolar kendisini yatak odasına kapatan genç adam telefonundan porno resimleri açtığı porno filmini keyifle seyir ederek yatağını mobil porno okşar ruh dinlendirici olduğunu iddia ettikleri özel sex resim bir masaj salonunda çalışan genç masör hem sağlık hem de huzur sikiş için gelip masaj yaptıracak olan kadını gördüğünde porn nutku tutulur tüm gün boyu seksi lezbiyenleri sikiş dikizleyerek onları en savunmasız anlarında fotoğraflayan azılı erkek lavaboya geçerek fotoğraflara bakıp koca yarağını keyifle okşamaya başlar
Predictive and Prognostic Value of ALK Gene Rearrangement in Non- Small Cell Lung Cancer | OMICS International| Abstract
ISSN: 2161-1165

Epidemiology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • Epidemiol 2014, Vol 4(1): 146
  • DOI: 10.4172/2161-1165.1000146

Predictive and Prognostic Value of ALK Gene Rearrangement in Non- Small Cell Lung Cancer

Kimary Kulig1, Shrividya Iyer2,4, Yi Wang3 and Ping Yang4
1Department of US Medical Oncology, , Bristol-Myers Squibb, Plainsboro, NJ, USA
2Division of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China
3Department of Global Health Economics and Outcomes Research, , Pfizer, Inc., New York, NY, USA
4Division of Epidemiology, Health Sciences Research, , Mayo Clinic, Rochester, MN, USA
*Corresponding Author :

Kimary Kulig, Yi Wang, Shrividya Iyer and Ping Yang

Received Date: Dec 03, 2013 / Accepted Date: Jan 26, 2014 / Published Date: Jan 28, 2014


Anaplastic Lymphoma Kinase (ALK) is a relatively new as an oncogenic driver and a therapeutic target in Non-Small Cell Lung Cancer (NSCLC); the prognostic and predictive implications of ALK-positivity in NSCLC is far from clear and no large-scale studies have been reported to date. In the current review, we summarize published data examining the variation in prognostic and predictive effect of ALK-positivity on clinical outcomes in NSCLC patients, based on the extent of control of or adjustment for known confounding factors such as smoking status, disease stage, and age by study design or analyses. ALK rearrangement in NSCLC did not appear to be predictive of improved outcomes with chemotherapy but was predictive of poor response to EGFR TKI therapy. Overall, ALK rearrangement was found to be a negative prognostic factor in NSCLC in studies controlling for known confounding factors. In addition to highlighting the importance of controlling for confounding factors in retrospective studies evaluating outcomes, our review also summarizes evidence of an unmet need in terms of poor response amongst ALK-positive NSCLC patients to standard therapies that do not target ALK.

Keywords: Anaplastic Lymphoma Kinase (ALK); Non-Small Cell Lung Cancer (NSCLC); Survival; Clinical Outcomes; Prognostic; Predictive; Review

Citation: Kulig K, Wang Y, Iyer S, Yang P (2014) Predictive and Prognostic Value of ALK Gene Rearrangement in Non-Small Cell Lung Cancer. Epidemiol 4:146. Doi: 10.4172/2161-1165.1000146

Copyright: © 2014 Kulig K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Article Usage
  • Total views: 16336
  • [From(publication date): 2-2014 - Oct 02, 2022]
  • Breakdown by view type
  • HTML page views: 11920
  • PDF downloads: 4416