alexa Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis | OMICS International | Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis

Tarhan G1, Yilmaz N2, Ilhan F3, Çeliker H4, Cesur S5* and Çiftçi A6
1Department of Medical Microbiology, Faculty of Medicine, Adiyaman University, Adıyaman,Turkey
2Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Bozok University, Yozgat, Turkey
3Department of Immunology, Faculty of Medicine, Firat University, Elazığ, Turkey
4Department of Internal Medicine, Faculty of Medicine, Firat University, Elazığ, Turkey
5Infectious Diseases and Clinical Microbiology Clinic, Ankara Education and Research Hospital, Ankara, Turkey
6Department of Internal Medicine, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey
Corresponding Author : Sarah Cesur
Infectious Diseases and Clinical Microbiology Clinic
Ankara Education and Research Hospital, Ankara, Turkey
Tel: +90-312-3103333
E-mail: [email protected]
Received: February 26, 2015 Accepted: July 13, 2015 Published: July 20, 2015
Citation: Tarhan G, Yilmaz N, Ilhan F, Çeliker H, Cesur S, et al. (2015) Prevalence of Human Herpes Virus 6 (HHV-6) in Patients with Hemodialysis. J Infect Dis Ther 3:224. doi:10.4172/2332-0877.1000224
Copyright: © 2015 Tarhan G et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

HHV-6 is the causative agent of exanthema subitum in children. The main modes of transmission of HHV-6 arebody secretions such as infected saliva but it can be transmitted with blood and blood products that are infected with\the virus. Therefore, it is thought that the immunocompromised hemodialysis patients who had multiple bloodtransfusions due to various reasons, and who collectively use devices such as hemodialysis machines are at risk forHHV-6 infection. The present study aimed to determine the incidence of HHV-6 infection in hemodialysis patients.
Twenty-five healthy individuals that were matched with 25 hemodialysis patients in terms of gender and age wereincluded in the study. The IgM and IgG sero-prevalence in the patient and control groups wereinvestigated with theindirect fluorescence antibody method and HHV-6 DNA prevalence and the determination of variant types (variant Aand variant B) were investigated with the PCR-RFLP molecular method. HHV-6 IgG and HHV-6 IgM antibodypositivity ratios in the patient and control groups were 76% and 20% respectively. Out of 50 serum samples of hemodialysis patients and healthy individuals, HHV-6 DNA was positive in seven of 25 samples of hemodialysispatients (28%) and it was positive in eight of 25 samples of the control group (32%). Variant analysis was performedwith the PCR-RFLP method in HHV-6 DNA positive hemodialysis patients and control patients. At the end of theanalysis, while variant A was not detected in the patient and control groups, variant B was detected in a total of 15individuals, including seven patients in the hemodialysis patient group and eight patients in the control group. Inconclusion, the researchers believe that there is a need for controlled studies including more samples to determinethe clinical importance of HHV-6 DNA and HHV-6 variants in hemodialysis patients.

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