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Putative Status of Actively Operative Performance Attributes as Determinants of Minimal Platform Oncogenesis in C-Myc Amplification | OMICS International| Abstract
ISSN 2472-0429

Advances in Cancer Prevention
Open Access

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  • Review Article   
  • Adv Cancer Prev 2016, Vol 1(2): 108
  • DOI: 10.4172/2472-0429.1000108

Putative Status of Actively Operative Performance Attributes as Determinants of Minimal Platform Oncogenesis in C-Myc Amplification

Lawrence M Agius*
Department of Pathology, Mater dei Hospital, Tal-qroqq, University of Malta Medical School, , MSIDA, Malta
*Corresponding Author : Lawrence M Agius, Department of Pathology, Mater dei Hospital, Tal-qroqq, University of Malta Medical School, MSIDA, Malta, Tel: +356-21451752, Email: [email protected]

Received Date: Apr 13, 2016 / Accepted Date: May 19, 2016 / Published Date: May 30, 2016

Abstract

Delivery and effective modulation of intrinsically operative c-Myc gene amplification is a referential series of system pathways that appear to condition minimal platform utilization of dimensions that characterizes the outcomes as hyper-proliferation and increased growth rate, on the one hand, and of enhanced apoptotic activity, on the other. A small numerical genetic requirement for oncogenesis appears sufficient in the case of some neoplasms such as human prostatic carcinoma. Thus, targeting c-Myc appears a highly promising endeavor to induce therapeutic regression of neoplasms. On the other hand, loss of dependence on c-Myc of certain subsets of tumors and recurrence after partial regression contrast with the arrest of some neoplasms that have been investigated in certain animal models. In terms that implicate the delivery of transforming potentiality of this amplified master-oncogene, it is significant to view potentiality of the already established increased proliferative rate within contexts of modulated sensitivity for the instability of the genome due to subsequent tumor progression. Accumulation of multiple genetic lesions, as seen in advanced clinically detected tumors, would attest to an autocrine and paracrine series of lesions that include increased apoptosis of neighboring normal cells, and also to the angiogenesis that re-characterizes the malignant transformation process as essentially metastasizing attributes of systemic spread.

Keywords: Autocrine; Paracrine; Prostatic carcinoma; Neoplasms

Citation: Agius LM (2016) Putative Status of Actively Operative Performance Attributes as Determinants of Minimal Platform Oncogenesis in C-Myc Amplification. Adv Cancer Prev 1: 108. Doi: 10.4172/2472-0429.1000108

Copyright: © 2016 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Mukul
    Posted on Aug 30 2016 at 3:15 pm
    The editorial imparts knowledge on the functional aspects of the currently used tools in the diagnosis as well as treatment of diseases. The author provides expert comments on the extant advantages as well as challenges associated with application of genomic tools in clinical studies and practice.
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