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Radiation-Induced Arterial Injury in the Upper Limb | OMICS International| Abstract

Atherosclerosis: Open Access
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  • Mini Review   
  • Atheroscler Open Access 2016, Vol 1(1): 103

Radiation-Induced Arterial Injury in the Upper Limb

Tetsuo Yamanaka*, Toru Fukatsu, Yoshimaro Ichinohe, Hirotaka Komatsu and Yasunobu Hirata
Department of Cardiovascular Medicine, Tokyo Teishin Hospital, , Chiyodaku, Tokyo, Japan
*Corresponding Author : Tetsuo Yamanaka, Department of Cardiovascular Medicine, Tokyo Teishin Hospital, Chiyodaku, Tokyo, Japan, Tel: +08-3-5214-7111, Email: [email protected]

Received Date: Apr 13, 2016 / Accepted Date: May 25, 2016 / Published Date: Jun 01, 2016


In recent years, radiation combination therapy for malignant tumors has improved cancer survival, thereby increasing the importance of radiation therapy. In 1959, radiation-induced arterial injury (RIAI) was first reported by Thomas as a condition in which stenosis and obstruction of the blood vessels arise within the irradiated area following radiation therapy; there have been several subsequent reports regarding this. Although RIAI has been examined and reported, to date, there have been few reports of RIAI in the arteries of the upper limbs, and it cannot be said that the clinical features and treatment of this condition have been thoroughly examined and established. In particular, irradiation for breast cancer can cause stenosis and obstruction in the area extending from the subclavian artery to the axillary artery; however, the associated symptoms resemble the symptoms of lymphedema and neuropathy following surgery for breast cancer, and it is assumed that diagnosis is difficult, and many patients has been overlooked. Thus, in the event of such patients, careful examination should be performed with RIAI in mind. Irradiation can cause arteriosclerosis, and therefore, it is important that RIAI becomes common knowledge; further examinations should also be conducted in a larger sample size.

Keywords: Radiation-induced arterial injury; Radiation therapy; Breast cancer

Citation: Tetsuo Y, Toru F, Yoshimaro I, Hirotaka K, Yasunobu H, et al. (2016) Radiation-Induced Arterial Injury in the Upper Limb . Atheroscler Open Access 1:103.

Copyright: © 2016 Tetsuo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Review summary

  1. Gabriel
    Posted on Aug 24 2016 at 3:59 pm
    The article highlighted the complications associated with the application of radiation therapy in the treatment of cancer. The author specifically highlighted the occurrence of stenosis and arteriosclerosis in breast cancer patients. The article emphasises the requirement of increase in awareness regarding the occurrence of radiation-induced arterial injury (RIAI) in cancer patients for the complete recovery of the patients.