Spectrophotometric Determination of Nifedipine and Nicardipine in their Pharmaceutical Preparations
- *Corresponding Author:
- Ahmed A. H. Abdellatif
Department of Pharmaceutics and Industrial pharmacy
Faculty of Pharmacy, Al Azhar University
Assuit 71524, Egypt
Tel: +20 1016660069
E-mail: [email protected]
Received date: September 19, 2015; Accepted date: September 30, 2015; Published date October 07, 2015
Citation: Hamd MAE, Abdellatif AAH, Derayea SM, Abdelmageed OH, Askal HF (2015) Spectrophotometric Determination of Nifedipine and Nicardipine in their Pharmaceutical Preparations. Ind Chem Open Access 1:103. doi:10.4172/2471-2663.1000103
Copyright: © 2015 Hamd MAE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A sensitive and selective spectrophotometric method was developed for determination of nifedipine (NIF) and nicardipine (NIC) in their pharmaceutical preparations. The method based on a rapid reduction of the nitro to primary amino groups using zinc dust and hydrochloric acid. The resulting primary aromatic amine was subjected to a condensation reaction with p-dimethyl amino benzaldehyde to produce a yellowish-green color of Schiff’s bases which quantified spectrophotometrically at the absorption maxima of 434 and 441 nm for NIF and NIC, respectively. Beer’s law was obeyed in the concentration ranges 2.0 to 12.0 μg/mL with a limit of quantitation 1.4 and 1.9 μg/mL and the mean percentage recoveries 98.2±0.3 to 99.5±0.3% NIF and NIC, respectively. The proposed methods were successfully applied to assay NIF and NIC in their capsules and tablets.