Spectrophotometric Estimation of Metaxalone and Diclofenac Potassium by Multicomponent Analytical Method from Tablet Dosage Form
- *Corresponding Author:
- Prachi V Kabra
Department of Quality Assurance
Nargund College of Pharmacy
Dattatreya Nagar, II-main, 100ft ring road
BSK IIIstage, Bangalore-85
E-mail: [email protected]
Received date: May 28, 2012; Accepted date: July 13, 2012; Published date: July 16, 2012
Citation: Patel CR, Kimbahune RV, Kabra PV, Harish AR, Nargund LVG (2012) Spectrophotometric Estimation of Metaxalone and Diclofenac Potassium by Multicomponent Analytical Method from Tablet Dosage Form. J Anal Bioanal Tech 3:137. doi: 10.4172/2155-9872.1000137
Copyright: © 2012 Patel CR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A simple Multicomponent Spectrophotometric method for simultaneous estimation of Metaxalone and Diclofenac Potassium in combined tablet dosage form had been proposed. Considering the absorption spectra of both analytes in the range of 220-350 nm in methanol, the four wavelengths of equal intervals of 40 nm were selected as 350 nm, 310 nm, 270 nm and 230 nm to produce calibration curves of mixture of analytes. The present method used inbuilt application of instrument (Shimadzu Pharm Spec 1700, UV spectrophotometer) to quantify Metaxalone and Diclofence potassium in formulation. The method had been validated in accordance with ICH guidelines for accuracy and precision.