alexa Stem Cell Therapy for Endothelial Dysfunction in the Coronary Circulation | OMICS International
ISSN: 2161-0479

Journal of Autacoids and Hormones
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Special Issue Article

Stem Cell Therapy for Endothelial Dysfunction in the Coronary Circulation

Wei Huang1, Ronald W. Millard2 and Yigang Wang1*
1Department of Pathology and Laboratory Medicine
2Department of Pharmacology & Cell Biophysics, Cardiovascular Center of Excellence, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
Corresponding Author : Yigang Wang, MD, PhD
Department of Pathology and Laboratory Medicine
University of Cincinnati Medical Center
231 Albert Sabin Way, Cincinnati, OH 45267-0529
Tel: 513-558-5798
Fax: 513-558-0807
E-mail: [email protected]
Received November 24, 2011; Accepted January 09, 2012; Published January 12, 2012
Citation: Huang W, Millard RW, Wang Y (2011) Stem Cell Therapy for Endothelial Dysfunction in the Coronary Circulation. Autacoids S3-001. doi: 10.4172/2161-0479.S3-001
Copyright: © 2011 Huang W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The endothelium is increasingly recognized as serving a critical role in maintaining circulatory homeostasis. Endothelial dysfunction is evidenced as an attenuation or exaggeration of the normal dynamic vasomotor range. Circulating endothelial progenitor cells (EPCs) are responsible for the endothelial replenishment. When EPC recruitment is insufficient after endothelial injury, endothelial pathophysiological ensues. Impaired endothelial function is associated with myriad cardiovascular diseases including coronary artery disease, atherosclerosis, hypertension, chronic heart failure, peripheral artery disease, diabetes, and chronic renal failure. Therefore, correction of endothelial dysfunction presents a therapeutic opportunity that, if met, could reduce adverse cardiovascular events. EPCs play an important role in maintaining endothelial function and might affect the progression of ischemic heart disease. The mechanisms underlying the salutary effect of EPCs involve EPC-mediated paracrine effects, EPC differentiation into endothelial cells, and promoting the repair of damaged endothelium. The implementation of EPCs is emerging as a new promising cell-based therapy for restoration of angiogenic activity in cardiovascular disease, which might be particularly beneficial. The goal of this article is to review and critically evaluate the relevant literature describing putative role of EPCs in the treatment of ischemic heart disease, especially that of the coronary arterial system, that is rooted in endothelial dysfunction.

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