alexa Subclinical Processes in the Development of Type Two Diabetes | OMICS International | Abstract
ISSN: 2165-7025

Journal of Novel Physiotherapies
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Mini Review

Subclinical Processes in the Development of Type Two Diabetes

Thiago Gomes Heck1,2*, Mirna Stela Ludwig1,2, Greice Franciele Feyh dos Santos Montagner1 and Matias Nunes Frizzo1
1 Research Group in Physiology (GPeF), Department of Life Sciences (DCVida), Regional University of Northwestern Rio Grande do Sul State (UNIJUÍ), Ijuí, RS, Brazil
2 Post graduate Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijuí, RS, Brazil
Corresponding Author : Thiago Gomes Heck
Research Group in Physiology (GPeF)
Department of Life Sciences (DCVida)
Regional University of Northwestern Rio
Grande do Sul State (UNIJUÍ), Ijuí, RS, Brazil
Tel: 55163602-458
E-mail: [email protected]
Received December 30, 2014; Accepted January 21, 2015; Published January 28, 2015
Citation: Heck TG, Ludwig MS, Montagner GFFDS, Frizzo MN (2015) Subclinical Processes in the Development of Type Two Diabetes. J Nov Physiother 5:246. doi: 10.4172/2165-7025.1000246
Copyright: © 2015 Heck TG et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The imbalance in metabolic homeostasis in type 2 diabetes (T2DM) is accompanied by cellular stress, altered expression and circulating concentration of heat shock proteins (HSP) and cytokines (pro and anti-inflammatory). Also T2DM subjects had altered redox state (oxidative stress) and erythrocytes parameters. This set of molecular, biochemical and immuno haematological alterations are usually subclinical events, but characterizes chemical and biological processes associated with the development of insulin resistance and the pathophysiology of T2DM. These process and markers of T2DM complications and development will be briefly outlined throughout this mini-review article. The establishment of new strategies for glycemic control required more attention and more studies about inflammatory related biomarkers in T2DM.

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