alexa Systemically Antagonizing L-Type Calcium Channels Modifies Intensity and Pattern of Fos Expression Evoked by Electrical Intracochlear Stimulation in the Adult Rat Auditory Brainstem
ISSN: 2161-119X

Otolaryngology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Systemically Antagonizing L-Type Calcium Channels Modifies Intensity and Pattern of Fos Expression Evoked by Electrical Intracochlear Stimulation in the Adult Rat Auditory Brainstem

Peter Bischoff, Nicole Rosskothen-Kuhl*,# and Robert-Benjamin Illing#

Department of Otorhinolaryngology, Neurobiological Research Laboratory, University of Freiburg, Germany

#Senior-authorship

Corresponding Author:
Nicole Rosskothen-Kuhl
Neurobiological Research Laboratory
University ENT Clinic Killianstr
Freiburg, Germany
Tel: +49 761 270 42650
Fax: +49 761 270 40750
E-mail: [email protected]

Received date: August 13, 2013; Accepted date: August 22, 2013; Published date: August 29, 2013

Citation: Bischoff P, Rosskothen-Kuhl N, Illing RB (2013) Systemically Antagonizing L-Type Calcium Channels Modifies Intensity and Pattern of Fos Expression Evoked by Electrical Intracochlear Stimulation in the Adult Rat Auditory Brainstem. Otolaryngology S3: 005 doi: 10.4172/2161-119X.S3-005 -

Copyright: © 2013 Bischoff P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Specific sensory activity such as sustained acoustical or Electrical Intracochlear Stimulation (EIS) elicits electrical responses and molecular changes in neuronal subpopulations of the auditory brainstem. One of the first molecular changes observed is the expression of the immediate early gene Fos. Its protein functions as a monomer of the transcription factor Activator Protein-1 (AP-1) which triggers cascades of protein synthesis that play a crucial role in neuroplastic remodeling. We investigated the pattern of Fos expression in Anteroventral (AVCN) and Dorsal Cochlear Nucleus (DCN) and Central Inferior Colliculus (CIC) following 2 h of unilateral EIS at 1.6, 50, and 400 Hz in anesthetized untreated and nimodipine-treated rats. Our data indicate that with increasing stimulation frequency the population of cells expressing Fos changed in composition and size in AVCN, DCN, and CIC. In all investigated auditory regions, systemic nimodipine treatment, an antagonist of L-type calcium channels, resulted in a significant increase in the number of neurons expressing Fos upon EIS compared to non-treated rats at the same stimulation parameters. Apparently, antagonizing L-type calcium channels enhances the responsiveness of neurons, and thus their readiness to respond with functional changes to sensory activity, in the auditory brainstem with little influence on the tonotopic precision of the response.

 

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version