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ISSN: 2165-7025

Journal of Novel Physiotherapies
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Research Article

Terbinafine Hydrochloride 1% Iontophoresis for the Treatment of Toenail Onychomycosis: A Randomized Placebo Controlled Study

Ahmed Fathy Samhan1,2* and Nermeen Mohamed Abdelhalim1,2
1Physical Therapy Department, New Kasr El-Aini Teaching Hospital, Faculty of Medicine, Cairo University, Egypt
2Physical Therapy and Health Rehabilitation Department, College of Applied Medical Sciences, Prince Sattam bin Abduaziz University (Formerly Salman bin Abdulaziz University), Saudi Arabia
Corresponding Author : Ahmed Fathy Samhan
PhD PT, Physical Therapy and Health Rehabilitation
Department, College of Applied Medical Sciences
Prince Sattam bin Abduaziz University
(Formerly Salman bin Abdulaziz University)
Alkharj, Saudi Arabia,
Tel: 00966545159701
E-mail: [email protected]
Received: March 01, 2015, Accepted: March 11, 2015, Published: March 18, 2015
Citation: Samhan AF, Abdelhalim NM (2015) Terbinafine Hydrochloride 1% Iontophoresis for the Treatment of Toenail Onychomycosis: A Randomized Placebo Controlled Study. J Nov Physiother 5:252. doi: 10.4172/2165-7025.1000252
Copyright: © 2015 Samhan AF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
 

Abstract

Background: Successful topical treatment with deep penetration of toenail onychomychosis remains hard as the delivery of effective degrees of antifungal drug to the site of action is very difficult.

Purpose: To evaluate the efficacy and safety of terbinafine hydrochloride 1% iontophoresis for treatment of toenail onychomychosis.

Methods: Forty patients (23 male and 17 female) with mean age 46.15 ± 7.72 and with mild-to-moderate toenail onychomycosis of the big toe, were enrolled in a randomized placebo controlled study. All patients were assigned randomly into two groups of equal number: study group received terbinafine hydrochloride 1% iontophoresis on the big toenail onychomycosis with an intensity of 3 to 4 mA/min for 30 minutes, 3 times per week for 4 weeks (12 sessions) and control group received placebo terbinafine hydrochloride 1% iontophoresis. Onychomychosis Severity Index, potassium hydroxide microscopy of a dermatophyte, and visual analogue scale for patient-reported pain during walking wearing shoes had been collected pre-treatment and post-treatment.

Results: Showed significant improvement in the 3 outcomes in study group (p<0.05) with non-significant improvement in control group (p>0.05). Moreover the analysis between the two groups showed highly significant improvement as the study group would be preferred.

Conclusion: Terbinafine hydrochloride 1% iontophoresis with an intensity of 3 to 4 mA/min appeared to be effective and safe for treatment of mild-to-moderate toenail onychomychosis after 4 weeks of treatment.

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