alexa The Effect of Tonsillectomy on the Salivary Immune Factors: A Systematic Review and Meta-Analysis
ISSN: 2161-119X

Otolaryngology: Open Access
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Effect of Tonsillectomy on the Salivary Immune Factors: A Systematic Review and Meta-Analysis

Mohamad A. Bitar*

Department of ENT Surgery, The Children’s Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia

Corresponding Author:
Mohamad A. Bitar
Department of ENT Surgery
The Children’s Hospital at Westmead
Locked Bag 4001, Westmead, NSW 2560, Australia
Tel: +575-937-1150
Fax: +61298452078
E-mail: [email protected]

Received date: January 21, 2015; Accepted date: February 16, 2015; Published date: February 25, 2015

Citation: Bitar MA (2015) The Effect of Tonsillectomy on the Salivary Immune Factors: A Systematic Review and Meta-Analysis. Otolaryngology 5:187. doi:10.4172/2161-119X.1000187

Copyright: © 2015 Bitar MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Background & objectives: The effect of tonsillectomy on the immune system is a controversial issue. The debate is largely based on contradictory findings in the literature. However, it is unlikely for tonsils to produce a negative systemic effect and it is more logical to think about a local effect that can be transient or long lasting. The aim of this systematic review is to analyze the observed changes in salivary immune factors following tonsillectomy and understand their clinical significance.

Materials & methods: Systematic review of the English literature was performed using Medline, Embase and Cochrane. We used the terms tonsillectomy, adenotonsillectomy, humoral immunity, immune system, saliva in various combination to look for pertinent studies. We excluded duplicate publications, reviews and studies that did not analyze salivary immune factors.

Results: Thirty four manuscripts studied the effect of tonsillectomy on the immune system. Only 9 of them (including 585 patients) looked at the effect on salivary immune factors. All studies analyzed the effect on salivary Immunoglobulin (Ig) A, four of them studied additional factors such as other salivary Ig’s, anti-microbial proteins (lactoferrin, peroxidases, lysozyme), anti-viral and anti-bacterial Ig’s. One study showed a significant decrease in salivary IgA, another showed a decrease in salivary IgG and a third showed a decrease in salivary IgM, lactoferrin and antimicrobial salivary IgG. Two studies had non-conclusive concerns regarding the observed changes in salivary immune factors, the third study recommended measuring salivary IgA pre and postoperatively. Only 11.1% of the studied patients had on the short term, a significant decrease in SecIgA level that can be attributed to tonsillectomy.

Conclusion: Tonsillectomy does not seem in general to negatively affect the host’s salivary immune defenses. The concerns raised are based on a partial apparent down-regulation of the some of the salivary immune components. More longitudinal studies are needed to really understand the clinical effect of any observed change in the salivary immune system.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_bi[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords