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The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep- Disordered Breathing Related Symptoms Caused By Hyperesthetic Non- Infectious Rhinitis| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngology 2014, Vol 4(1): 150
  • DOI: 10.4172/2161-119X.1000150

The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep- Disordered Breathing Related Symptoms Caused By Hyperesthetic Non- Infectious Rhinitis

Hirotaka Hara*, Kazuma Sugahara, Takefumi Mikuriya, Makoto Hashimoto, Shinsaku Tahara and Hiroshi Yamashita
Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, , Ube, Japan
*Corresponding Author : Hirotaka Hara, Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan, Tel: 81-836-22- 2280, Fax: 81-836-22-2280, Email: [email protected]

Received Date: Nov 26, 2013 / Accepted Date: Dec 12, 2013 / Published Date: Dec 20, 2013

Abstract

Objectives: The aims of this study were to prospectively evaluate the effectiveness of oral epinastine hydrochloride in pediatric outpatients with Sleep-Disordered Breathing- (SDB) related symptoms caused by hyperesthetic non-infectious rhinitis, and to assess their Quality of Life (QOL) prior to and following treatment.

Study design: Prospective

Methods: Pediatric outpatients (9 boys and 10 girls; average age, 5.6 years [SD=1.4]), with SDB related symptoms influenced by hyperesthetic non-infectious rhinitis were recruited. The children were all treated with oral epinastine hydrochloride dry syrup for 4 weeks. Before and after the 4-week treatment period, the following data were collected from each participant: otolaryngological findings, obstructive sleep apnea-18 (OSA-18) scores, and evaluation of QOL.

Results: Epinastine hydrochloride significantly improved the swelling of the inferior nasal turbinate mucosa and decreased the quantity of nasal discharge. The initial total mean OSA-18 score was 58.5, whereas the total score reduced to 22.8 after oral epinastine hydrochloride treatment. Significant (p < 0.01) differences were found between pre- and post-treatment total OSA-18 scores as well as pre- and post-treatment measurements of domains of sleep disturbance, physical symptoms, and caregiver concerns.

Conclusions: Epinastine hydrochloride therapy may improve nasal findings and QOL in pediatric outpatients with SDB related symptoms caused by hyperesthetic non-infectious rhinitis.

Keywords: Epinastine hydrochloride, Pediatrics, Hyperesthetic noninfectious rhinitis, Allergic rhinitis, Sleep-disordered breathing, OSA- 18

Citation: Hara H, Sugahara K, Mikuriya T, Hashimoto M, Tahara S, et al. (2013) The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep-Disordered Breathing Related Symptoms Caused By Hyperesthetic Non-Infectious Rhinitis. Otolaryngology 4:150. Doi: 10.4172/2161-119X.1000150

Copyright: © 2013 Hara H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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