alexa The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep- Disordered Breathing Related Symptoms Caused By Hyperesthetic Non- Infectious Rhinitis
ISSN: 2161-119X

Otolaryngology: Open Access
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Research Article

The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep- Disordered Breathing Related Symptoms Caused By Hyperesthetic Non- Infectious Rhinitis

`Hirotaka Hara*, Kazuma Sugahara, Takefumi Mikuriya, Makoto Hashimoto, Shinsaku Tahara and Hiroshi Yamashita

Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, Ube, Japan

Corresponding Author:
Hirotaka Hara
Department of Otolaryngology
Yamaguchi University Graduate School of Medicine
Ube, Yamaguchi, Japan
Tel: 81-836-22-2280
Fax: 81-836-22-2280
E-mail: [email protected]

Received date: November 26, 2013; Accepted date: December 12, 2013; Published date: December 20, 2013

Citation: Hara H, Sugahara K, Mikuriya T, Hashimoto M, Tahara S, et al. (2013) The Effectiveness of Epinastine Hydrochloride for Pediatric Sleep-Disordered Breathing Related Symptoms Caused By Hyperesthetic Non-Infectious Rhinitis. Otolaryngology 4:150. doi:10.4172/2161- 119X.1000150

Copyright: © 2013 Hara H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: The aims of this study were to prospectively evaluate the effectiveness of oral epinastine hydrochloride in pediatric outpatients with Sleep-Disordered Breathing- (SDB) related symptoms caused by hyperesthetic non-infectious rhinitis, and to assess their Quality of Life (QOL) prior to and following treatment.

Study design: Prospective

Methods: Pediatric outpatients (9 boys and 10 girls; average age, 5.6 years [SD=1.4]), with SDB related symptoms influenced by hyperesthetic non-infectious rhinitis were recruited. The children were all treated with oral epinastine hydrochloride dry syrup for 4 weeks. Before and after the 4-week treatment period, the following data were collected from each participant: otolaryngological findings, obstructive sleep apnea-18 (OSA-18) scores, and evaluation of QOL.

Results: Epinastine hydrochloride significantly improved the swelling of the inferior nasal turbinate mucosa and decreased the quantity of nasal discharge. The initial total mean OSA-18 score was 58.5, whereas the total score reduced to 22.8 after oral epinastine hydrochloride treatment. Significant (p < 0.01) differences were found between pre- and post-treatment total OSA-18 scores as well as pre- and post-treatment measurements of domains of sleep disturbance, physical symptoms, and caregiver concerns.

Conclusions: Epinastine hydrochloride therapy may improve nasal findings and QOL in pediatric outpatients with SDB related symptoms caused by hyperesthetic non-infectious rhinitis.


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