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The Effects of 6and#946;-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial | OMICS International | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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Research Article

The Effects of 6β-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial

John Mendelson1*, Linghui Li1, Keith Flower1, Will Harris1, Jeremy R Coyle1, C Y Angie Chen1, Wolfgang Sadee2 and Gantt P Galloway1
1Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, , San Francisco, CA, USA
2Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus OH 43210, USA
*Corresponding Author: John Mendelson MD, Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA, United States, Tel: (415)-641-3370, Fax: (415)-641-3380, Email: [email protected]

Received Date: Jan 19, 2011 / Accepted Date: Apr 14, 2011 / Published Date: Apr 20, 2011

Citation: Mendelson J, Li L, Flower K, Harris W, Coyle JR, et al. (2011) The Effects of 6?-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial. J Addict Res Ther 2:108.DOI: 10.4172/2155-6105.1000108

Copyright: © 2010 Mendelson J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Potential complications of prescription opioid use include abuse and constipation. 6β-Naltrexol (6βNTX), a neutral opioid antagonist, may alleviate these complications when co-formulated with μ-opioid analgesics. In a double-blind ascending dose study, four subjects on methadone maintenance received 6βNTX (0.05, 0.15, 0.50 and 1.0 mg). 6βNTX was generally well tolerated; three of four subjects reported willingness to take higher doses. Increased gastrointestinal activity was evidenced by decreased oral-cecal transit time and prompt laxation at higher doses.

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Citations : 4229

Journal of Addiction Research & Therapy received 4229 citations as per Google Scholar report

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