alexa

GET THE APP

The Effects of the Benzodiazepine, Temazepam, on Neurocognitive Functioning and Sleep Patterns in Methamphetamine-Dependent Participants | OMICS International | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Effects of the Benzodiazepine, Temazepam, on Neurocognitive Functioning and Sleep Patterns in Methamphetamine-Dependent Participants

James J. Mahoney III1,2*, Brian J. Jackson1,2, Ari D. Kalechstein1,2, Richard De La Garza II1,2, Ravi Shah1,2, Chandra S. Nerumalla1,2 and Thomas F. Newton1,2

1Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, Texas, USA

2Michael E. DeBakey VA Medical Center, Houston, Texas, USA

*Corresponding Author:
James J. Mahoney
Baylor College of Medicine
Menninger Department of Psychiatry and Behavioral Sciences
Michael E. DeBakey VA Medical Center, Houston, Texas, USA
E-mail: [email protected]

Received November 13, 2011; Accepted January 06, 2012; Published January 12, 2012

Citation: Mahoney III JJ, Jackson BJ, Kalechstein AD, Garza II RDL, Shah R, et al. (2012) The Effects of the Benzodiazepine, Temazepam, on Neurocognitive Functioning and Sleep Patterns in Methamphetamine-Dependent Participants. J Addict Res Ther S1:007. doi:10.4172/2155-6105.S1-007

Copyright: © 2012 Mahoney III JJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: Previous research has shown that methamphetamine users demonstrate poorer sleep quality and daytime sleepiness when compared to healthy controls. It is also well known that long-term methamphetamine use is associated with impaired neurocognitive function and, similarly, sleep deprivation is associated with decreased neurocognitive performance. Temazepam is a potent sedative and is effective for the treatment of insomnia. It was hypothesized that treatment of methamphetamine dependent volunteers with temazepam would improve sleep characteristics resulting in improved cognitive functioning.

Methods: 18 subjects completed a seven-day inpatient study where they completed daily subjective assessments, such as the PSQI, ESS, and VAS. Temazepam or placebo was administered on the evenings of Nights 5 and 6. Sleepiness was objectively assessed using the MSLT on Days 5-7 and neurocognitive testing was performed on Day 5 (prior to drug administration) and on Day 7.

Results: The findings of this study demonstrate that temazepam did not improve quality of sleep, did not decrease sleep onset latency, and did not improve in neurocognition in methamphetamine-dependent participants.

Discussion: Since the chosen dose and duration of temazepam did not improve neurocognitive performance when compared to placebo, further research must be performed to better understand temazepam’s effects and potential utility in this population.

Keywords

https://www.thefinestreplica.com
Top