In order to analyze the effect of host HLA types on resistance or susceptibility to HIV infection and to study the HLA profile Of Ethiopian HIV/AIDS subjects DNA based HLA typing was carried out on 239 discordant, concordant couples and full blown HIV AIDS subjects. Our study showed that there was a clear difference between discordant positives and discordant negative couples, and discordant positives and concordant couples in their genetic profiles. Ethiopian AIDS patients were different from Ethiopian concordant couples in their very significant to significant association with HLA-A*29, *18, and *41; HLA-B*0705, *1517, *4101, *5001, *7301 and *18; HLA-C*0501, *0701, and *0740. AIDS patients were also very significantly different from discordant positives in their associations with HLA-A*68, HLA-B*39 and HLA- DR*11. AIDS patient were also different from discordant negatives in their very highly significant to highly significant association with HLA-*0801, *1817, *352001 and *4901; HLA-C*7 and HLADR* 40301. Discordant positive subjects were found to be more heterozygous at all loci (HLA-A, B, C and HLA-DR) when compared with concordant couples and HIV/AIDS subjects.