alexa The Preparation of Silk Fibroin Modified Pbt-Co-Pbs/Peg
ISSN: 1662-100X

Journal of Biomimetics Biomaterials and Tissue Engineering
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

The Preparation of Silk Fibroin Modified Pbt-Co-Pbs/Peg Composite Films and their Effects on Clinical Human Salivary Epithelial Cells Transplantation

Jie Zhu1*, Yueming Zhang1, Zhicheng Tao1, Nanwei Xu2, Liqun Wang1* and Xiaolin Zhu1

1School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China

2Department of Orthopaedics, Changzhou No.2 People’s Hospital, Changzhou 213003, China

Corresponding Authors:
Jie Zhu
School of Pharmaceutical Engineering & Life Science
Changzhou University, Changzhou 213164, China
Tel: 86-519-86334597
Fax: 86-519-86334597
E-mail: [email protected]
Liqun Wang
School of Pharmaceutical Engineering & Life Science
Changzhou University, Changzhou 213164, China
E-mail: [email protected]

Received date April 23, 2013; Accepted date July 08, 2013; Published date July 16, 2013

Citation: Zhu J, Zhang Y, Tao Z, Xu N, Wang L, et al. (2013) The Preparation of Silk Fibroin Modified PBT-co-PBS/PEG Composite Films and their Effects on Clinical Human Salivary Epithelial Cells Transplantation. J Biomim Biomater Tissue Eng 18:107. doi: 10.4172/1662-100X.1000107

Copyright: © 2013 Zhu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



We reported the preparation of surface modified poly(butylene terephthalate)-co-poly(butylene succinate)-bpoly( ethylene glycol) (i.e. PBT-co-PBS/PEG) films by three methods: silk fibroin coating, SO2 plasma treatment and silk fibroin anchoring. The obtained composite films were named SF/(PBT-co-PBS/PEG), SO2/(PBT-co-PBS/PEG) and SF/ SO2/(PBT-co-PBS/PEG), respectively. Their surface properties were characterized by contact angles, surface energies and XPS. The biocompatibility of the films were further evaluated by in vitro and in vivo tests including the morphology, attachment, proliferation and viability of human salivary epithelial cells (HSG cells) and the following histological observation of the films implanting in Sprague Dawley rattus norregicus (SD rat). Results revealed that SF/SO2/(PBTco- PBS/PEG) possessed the high surface free energy (59.67 mJ/m2) and could immobilize a great amount of fibroin (SF surface coverage: 26.39 wt%), which attributed to the formation of such polar groups as hydrosulfide group, sulfonic group, carboxyl and carbonyl ones in the process of SO2 plasma treatment. The tests in vitro and in vivo suggested that the silk fibroin anchoring could significantly enhance the biocompatibility of PBT-co-PBS/PEG, which implied the potential application of fibroin modified PBT-co-PBS/PEG for clinical HSG cells transplantation in artificial salivary gland constructs.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version