The Role of TREM2 in Alzheimer's Disease and Other Neurological Disorders
- Corresponding Author:
- Thomas Wisniewski
New York University School of Medicine, Alexandria ERSP, Rm 802
450 East 29th St. New York, NY 10016, USA
Tel: (212) 263-7993
Fax: (212) 263-7528
Received date: January 20, 2014; Accepted date: October 01, 2014; Published date: October 06, 2014
Citation: Yaghmoor F, Noorsaeed A, Alsaggaf S, Aljohami W, Scholtzova H, et al. (2014) The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders. J Alzheimers Dis Parkinsonism 4: 160.doi: 10.4172/2161-0460.1000160
Copyright: © 2014 Yaghmoor F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer's disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors includediabetes mellitus, level of physical activity, educational status, hypertension and head injury. The most well known genetic risk factor for LOAD is inheritance of the apolipoprotein (apo) E4 allele. Recently, rare variants of TREM2 have been reported as a significant risk factor for LOAD, comparable to inheritance of apoE4. In this review we will focus on the role(s) of TREM2 in AD as well as in other neurodegenerative disorders.