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Validity of Markers and Indexes of Systemic Inflammation in Predicting Mortality in COVID-19 infection: A Hospital based Cross Sectional Study | OMICS International| Abstract
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Journal of Cardiac and Pulmonary Rehabilitation
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  • Research Article   
  • J Card Pulm Rehabil,
  • DOI: 10.4172/jcpr.1000146

Validity of Markers and Indexes of Systemic Inflammation in Predicting Mortality in COVID-19 infection: A Hospital based Cross Sectional Study

Archana B1,2*, Shylaja Shyamsunder3 and Rinki Das4
1Department of Pulmonary Medicine, Rajarajeswari Medical College and Hospital, Bengaluru, India
2Department of Pulmonary Medicine, Bhagawan Mahaveer Jain hospital, Girinagar, Bangalore, India
3Department of General Medicine, Bhagawan Mahaveer Jain hospital, Girinagar, Bangalore, India
4Department of Critical Care and Emergency Medicine, Bhagawan Mahaveer Jain hospital, Girinagar, Bangalore, India
*Corresponding Author : Dr. Archana B, Department of Pulmonary Medicine, Rajarajeswari Medical College and Hospital, Bengaluru-560074, India Exn. +91-974-101-6606, Email: [email protected]

Received Date: Aug 23, 2021 / Accepted Date: Sep 06, 2021 / Published Date: Sep 13, 2021

Abstract

Background: Corona virus disease 2019 (COVID-19) is an ongoing global pandemic. It is a systemic infection with a significant impact on the hematopoietic and the immune system. In this study we aimed to evaluate the different inflammatory markers and indexes of systemic inflammatory response in predicting the mortality in patients with COVID-19.

Methods: In this cross sectional study, various inflammatory markers like D-dimer, CRP, serum ferritin, LDH and CBC derived indexes of inflammation were analyzed in predicting mortality in COVID-19 infection.

Results: We enrolled 302 COVID-19 patients who had a mean age of 54.51 ± 15.39 yrs. with 210 (69.5%) males. Among them 21% were asymptomatic and fever was the commonest among symptomatic patients. Majority of patients (66.7%) had no comorbidities and 20% had multiple comorbidities. On analyzing different hematological variables, survivors had statistically significant higher hemoglobin count, lymphocytes, monocytes, eosinophil and platelet count and lower leukocyte, neutrophil count. Inflammatory markers D-dimer, serum ferritin and LDH were significantly elevated among non survivors. Among the indexes of inflammation, only NLR showed significant higher values among non survivors.

All the inflammatory markers were able to predict mortality among the COVID-19 infected cases with a sensitivity and specificity of 85% and 65% for D dimer levels, 85% and 72% for serum ferritin, 85% and 72% for LDH, 85% and 51% for CRP levels respectively. Among the indexes of inflammation, validity of NLR was best in predicting mortality with 85% sensitivity and 51% specificity.

Conclusion: Abnormalities in peripheral blood parameters and increase in inflammatory markers are common findings in COVID-19 infection. NLR was best at predicting mortality followed by D-dimer and serum ferritin levels.

Keywords: Coronavirus; COVID-19; D dimer; Inflammatory markers; Neutrophil lymphocyte ratio; Systemic inflammation index

Citation: Archana B, Shyamsunder S, Das R (2021) Validity of Markers and Indexes of Systemic Inflammation in Predicting Mortality in COVID-19 infection: A Hospital based Cross Sectional Study. J Card Pulm Rehabil 5: 146. Doi: 10.4172/jcpr.1000146

Copyright: © 2021 Archana B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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