3D-QSAR CoMFA And CoMSIA Approaches To Develop 5-lipoxygenase Inhibitors | 5989
Journal of Analytical & Bioanalytical Techniques
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Several herbal formulations are available which are said to have effect on Parkinson?s disease. These drugs directly or indirectly
affect the dopamine levels in brain. For example, Zandopa is an herbal remedy for the treatment of Parkinson's disease which
contains richest natural sources of L-dopa, the plasma half life of which is similar to that from synthetic L-dopa; hence frequency
of dosage is comparable.
Pramipexole dihydrochloride (PPD) a nonergot dopamine agonist used for treatment of Parkinson's disease. The ability
of PPD to alleviate the signs and symptoms of Parkinson's disease is supposed to be linked to its ability to stimulate dopamine
receptors in the striatum.
Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine. It is a neurotransmitter
in certain areas of the central nervous system. Dopamine is accomplished directly by exerting an agonist action on beta-
Since herbal drugs are available over the counter and as they are believed to be effective, without side effects they are
consumed along with allopathic formulations. In such cases drug herb interactions are likely to take place and affect the efficiency
of treatment by different mechanisms.
So, the present work aims at development and validation of dopamine and PPD for assessment of influence of herbal
antiparkinson?s drug on the activity of PPD.
K.Kinnera is a student from JSS College of Pharmacy doing masters in Pharmaceutical Analysis. Presented a poster on ? Apoptosis ? New approach
for the cancer drug development? held at National Level Technical Pharma Symposium, PHARMACOLLATE?10, TRR college of Pharmacy, Meerpet,
Hyderabad. Presented a poster on ?Enhancement of Dissolution of Ritonavir by Solid dispersion Technology? held at International Conference on
?Imbibing Pharmaceutical Knowledge to the Professionals? at Lalitha College of Pharmacy, 2011, Hyderabad.
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