A Simple Hollow Fiber Liquid Phase Micro-extraction Combined With HPLC-UV Method For The Extraction, Pre-concentration And Determination Of Olanzapine In The Biological Samples | 10263
Journal of Analytical & Bioanalytical Techniques
Like us on:
Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Olanzapine (OZP) is a selective monoaminergic antagonist with high binding affinity to serotonin, dopamine and muscarinic
receptors. It has been proposed that this drug?s efficacy in schizophrenia is mediated through a combination of dopamine
and serotonin type 2 antagonism. A new method based on three-phase hollow-fiber liquid phase micro-extraction combined
with high performance liquid chromatography with UV detection (HF-LPME-HPLC-UV) was used for the extraction, pre-
concentration and determination of OZP in urine and plasma samples. Experimental parameters which control extraction
efficiency, such as type of organic solvent, pH of donor and acceptor phase, ionic strength of the sample, stirring rate, extraction
temperature and extraction time were studied. The limit of detection and relative standard deviation (n=5) of the method were
and 2.1%. Under the optimized conditions, enrichment factors up to 110 were achieved. Olanzapine was successfully
determined in urine and plasma samples without any significant matrix effect.
Mahnaz Qomi has done Ph.D. in analytical chemistry from Research and Sciences of Islamic Azad University, Tehran, Iran. She is an assistant
professor for 5 years in Pharmaceutical Sciences Branch of Islamic Azad University, Tehran, Iran. She is a researcher manager in the Pharmaceutical
Sciences Research Center at this university with more than 8 published papers in reputed journals.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals